2-Bromo-6-chloropyridin-3-amine

Base Information

• Chemical Name: 2-Bromo-6-chloropyridin-3-amine
• CAS No.: 1050501-88-6
• Molecular Formula: C5H4BrClN2
• Molecular Weight: 207.457
• Hs Code.: 2933399090
• Mol file: 1050501-88-6.mol

Synonyms:2-bromo-6-chloro-pyridin-3-amine;3-pyridinamine, 2-bromo-6-chloro-;3-Amino-2-bromo-6-chloropyridine;

Chemical Property of 2-Bromo-6-chloropyridin-3-amine

Chemical Property:

• Boiling Point: 330.261 °C at 760 mmHg
• PKA: -0.12±0.10(Predicted)
• Flash Point: 153.537 °C
• PSA: 38.91000
• Density: 1.835 g/cm³
• LogP: 2.66090
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromo-6-chloro-3-pyridinamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Bromo-6-chloro-3-pyridinamine is a reactant used in the synthesis of kilogram quantities of an akt Kinase inhibitor. It is mainly used as starting material for the production of many pharmaceutical compounds.

Technology Process of 2-Bromo-6-chloropyridin-3-amine

There total 1 articles about 2-Bromo-6-chloropyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.8%

6-Chloro-pyridin-3-ylamine (5350-93-6) → 2-bromo-6-chloro-pyridin-3-amine (1050501-88-6)

Guidance literature:

6-Chloro-pyridin-3-ylamine; With bromine; sodium acetate; acetic acid; at 20 ℃; for 1h;

With water; sodium carbonate; sodium chloride; In ethyl acetate;

Reference yield: 100.0%

2-bromo-6-chloro-pyridin-3-amine (1050501-88-6) + (2,6-dimethoxyphenyl)boronic acid (23112-96-1) → 6-chloro-2-(2,6-dimethoxyphenyl)pyridin-3-amine

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; at 90 ℃; for 3h; Inert atmosphere;

Reference yield: 83.0%

di-tert-butyl dicarbonate (24424-99-5) + 2-bromo-6-chloro-pyridin-3-amine (1050501-88-6) → tert-butyl (2-bromo-6-chloropyridin-3-yl)carbamate (1227958-32-8)

Guidance literature:

With sodium hexamethyldisilazane; In tetrahydrofuran; at -5 - 20 ℃; for 2.5h; Inert atmosphere;

DOI:10.1021/op300031r

upstream raw materials:

6-Chloro-pyridin-3-ylamine

Downstream raw materials:

3-amino-6-chloro-pyridine-2-carboxylic acid ethyl ester

5-chloro-1H-pyrrolo[3 ,2-b]pyridine-2-carboxylic acid

1-(difluoromethyl)-8-phenyl[1,2,4]triazolo[4,3-a][1,5]-naphthyridin-7(6H)-one

1-(difluoromethyl)-8-phenyl[1,2,4]triazolo[4,3-a][1,5]-naphthyridin-7-yl trifluoromethanesulfonate

Refernces

• 1、 -. "INHIBITORS OF LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE (LMPTP) AND USES THEREOF". Paragraph 00471. . Retrieved 2018/11/26.
• 2、 -. "RSV ANTIVIRAL COMPOUNDS". Page/Page column 56. . Retrieved 2014/05/07.