C₁₂H₁₆FNO₂

Base Information

• Chemical Name: C₁₂H₁₆FNO₂
• CAS No.: 1351781-71-9
• Molecular Formula: C₁₂H₁₆FNO₂
• Molecular Weight: 225.263
• Mol file: 1351781-71-9.mol

Synonyms:

Chemical Property of C₁₂H₁₆FNO₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₂H₁₆FNO₂

There total 5 articles about C₁₂H₁₆FNO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

ethyl 2-methoxyacetate (3938-96-3) + 4-fluoroamphetamine (459-02-9) → C12H16FNO2 (1351781-71-9) + (S)‐4‐fluoro‐α‐methylphenethylamine (788123-23-9) + (R)-(-)-α-methyl-β-(4-fluorophenyl)ethylamine (72522-20-4)

Guidance literature:

With Candida antartica lipase B; triethylamine; at 35 ℃; for 5.5h; optical yield given as %ee; Inert atmosphere; Enzymatic reaction;

DOI:10.1039/c1ob06251d

Reference yield:

C9H10FN → C12H16FNO2 (1351781-71-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 3 h / 20 °C

2: Candida antartica lipase B; triethylamine / 5.5 h / 35 °C / Inert atmosphere; Enzymatic reaction

With sodium tetrahydroborate; Candida antartica lipase B; triethylamine; In methanol;

DOI:10.1039/c1ob06251d

Reference yield:

4-fluorophenyl acetone (459-03-0) → C12H16FNO2 (1351781-71-9)

Guidance literature:

Multi-step reaction with 3 steps

1: titanium(IV) isopropylate; ammonia / methanol / 6 h / 20 °C / Inert atmosphere

2: sodium tetrahydroborate / methanol / 3 h / 20 °C

3: Candida antartica lipase B; triethylamine / 5.5 h / 35 °C / Inert atmosphere; Enzymatic reaction

With titanium(IV) isopropylate; sodium tetrahydroborate; Candida antartica lipase B; ammonia; triethylamine; In methanol;

DOI:10.1039/c1ob06251d

upstream raw materials:

ethyl 2-methoxyacetate

4-fluoroamphetamine

4-fluorophenyl acetone

1-(4-fluorophenyl)-2-nitropropene

Downstream raw materials:

(R)-(-)-α-methyl-β-(4-fluorophenyl)ethylamine

Refernces