2-methoxy-1,3-dioxane

Base Information

• Chemical Name: 2-methoxy-1,3-dioxane
• CAS No.: 17230-31-8
• Molecular Formula: C5H10 O3
• Molecular Weight: 118.133
• Mol file: 17230-31-8.mol

Synonyms:Orthoformicacid, cyclic trimethylene methyl ester (8CI); 1,3-Propanediol, cyclic methylorthoformate (8CI); 2-Methoxy-1,3-dioxane; NSC 378223

Chemical Property of 2-methoxy-1,3-dioxane

Chemical Property:

• Vapor Pressure: 6.5mmHg at 25°C
• Boiling Point: 144.1°C at 760 mmHg
• Flash Point: 43.8°C
• Density: 1.05g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-methoxy-1,3-dioxane

There total 2 articles about 2-methoxy-1,3-dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

trimethyleneglycol (504-63-2) + trimethyl orthoformate (149-73-5) → 2-methoxy-1,3-dioxane (17230-31-8)

Guidance literature:

With camphor-10-sulfonic acid; In dichloromethane; at 20 ℃; for 20h;

DOI:10.1002/1099-0682(200210)2002:10<2569::AID-EJIC2569>3.0.CO;2-5

Reference yield:

2-isopropoxy-1,3-dioxolane (75317-09-8) → C6H11O3 (17230-31-8)

Guidance literature:

With water; hexachloroiridate(IV);

DOI:10.1021/ja00271a004

Reference yield: 77.0%

2-methoxy-1,3-dioxane (17230-31-8) + 1-(Trimethylsilyloxy)cyclohexene (6651-36-1) → 2-(1,3-Dioxan-2-yl)cyclohexanon (99601-20-4)

Guidance literature:

With zinc(II) chloride; In diethyl ether; dichloromethane; for 1h; Ambient temperature;

upstream raw materials:

trimethyleneglycol

trimethyl orthoformate

2-isopropoxy-1,3-dioxolane

Downstream raw materials:

N-methylpyridinium chloride

allyl alcohol

2-(1',3'-dioxan-2'-yl)-1-phenylethanone

2-(1,3-Dioxan-2-yl)cyclohexanon

Refernces

• 1、 Bartels, Bjoern,Garcia-Yebra, Cristina,Rominger, Frank,Helmchen, Guenter. "Iridium-catalysed allylic substitution: Stereochemical aspects and isolation of IrIII complexes related to the catalytic cycle". . p. 2569 - 2586. Retrieved 2007/10/03.
• 2、 Roush, William R.,Gillis, Herbert R.. "Improved Synthesis of the Perhydroindenone Precursor of Dendrobine". . p. 4283 - 4287. Retrieved 2007/10/02.