Intermediate Formation

Characterization Stereoselective synthesis Optimization Protection of Functional Groups Starting Material Retrosynthetic analysis Purification and characterization Workup and Isolation Product Formation Workup Starting Materials Purification and Isolation Purification and Analysis Functional Group Transformations Substrate Preparation Chiral Auxiliary Introduction Enantioselective Addition of Amino Groups De-Protection Second Amino Group Addition Auxiliary Removal Final Purification and Isolation Chiral Analysis Completion Final Product Biological Activity Testing Friedel-Crafts Alkylation Key Sigmatropic Rearrangements Sequential Transformations Chiral Induction First Claisen Rearrangement Second Claisen Rearrangement Intermediate with Two Rings Two-Directional Ring-Closing Metathesis Palladium-Catalyzed Carbosilylation Sakurai-Type Cyclization Diversity and Modifications Ring Enlargement Annulation Reaction Palladium-Catalyzed Cycloalkenylation Select Your Starting Materials Ene Reaction 1 Ene Reaction 2 Repeat if Necessary Tune Reaction Conditions Fine-Tuning Nucleophilic Addition of Trimethylsilylacetylene (TMSA) Trimethylsilyl Group Cleavage