101277-90-1Relevant articles and documents
Microwave-promoted Suzuki-Miyaura coupling of arylboronic acids with 1-bromo-2-naphthol, o-bromophenol, and o-chlorophenol
Wawrzyniak, Piotr,Heinicke, Joachim
, p. 8921 - 8924 (2006)
In this letter we report a simple and efficient way for the direct Suzuki-Miyaura cross-coupling of unprotected 2-hydroxyaryl bromides and of 2-chlorophenol with arylboronic acids using suitable phosphine/Pd(OAc)2 catalysts systems with moist K3PO4/toluene or moist CsF/dioxane and microwave heating (20 min 105 °C to 3 h 100-120 °C) with an internal temperature control providing 2-hydroxybiaryls in yields up to 98%.
C-H functionalization directed by transformable nitrogen heterocycles: Synthesis of ortho-oxygenated arylnaphthalenes from arylphthalazines
Rastogi, Shiva K.,Medellin, Derek C.,Kornienko, Alexander
, p. 410 - 413 (2014/01/06)
Two protocols for oxygenation of aromatic C-H bonds ortho-positioned to the phthalazine ring were developed. The transannulation of the phthalazine ring to a naphthalene moiety by an Inverse Electron Demand Diels-Alder (IEDDA) reaction led to the synthesis of naphtho[2,1-c]chromenes, 1-(ortho-hydroxyaryl) naphthalenes and 6,7-dihydrobenzo[b]naphtho[1,2-d]oxepine. This new strategy based on the utilization of transformable nitrogen heterocycles in C-H functionalization chemistry can be potentially applicable to the synthesis of a broad range of biaryl compounds.
