101396-02-5Relevant articles and documents
Direct addition of supercritical alcohols, acetone or acetonitrile to the alkenes without catalysts
Kamitanaka, Takashi,Hikida, Tatsuyoshi,Hayashi, Satoshi,Kishida, Nobuhiro,Matsuda, Tomoko,Harada, Tadao
, p. 8460 - 8463 (2007)
The reactions of the alkenes with supercritical organic compounds under non-catalytic conditions were investigated. The H and CR2OH, CH2C{double bond, long}OCH3 or CH2C{triple bond, long}N of supercritical alcohols (CHR2OH), acetone (CH3C{double bond, long}OCH3) or acetonitrile (CH3C{triple bond, long}N) added to the C{double bond, long}C bonds of alkenes form C-C bonds between the α-carbons of the supercritical organic compounds and the sp2 carbons of the alkenes.
Palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides
Fan, Tao,Meng, Wei-Dong,Zhang, Xingang
, p. 2610 - 2616 (2017)
An efficient palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides has been developed. The reaction proceeds under mild reaction conditions with high efficiency and excellent functional group tolerance, even towards formyl
Decarboxylative Borylation of Stabilized and Activated Carbon Radicals
Li, Xiaojuan,Ni, Shengyang,Pan, Yi,Wang, Yi,Zhang, Qiang,Zhang, Weigang
, p. 21875 - 21879 (2020)
Redox-active esters (RAEs) as active radical precursors have been extensively studied for C?B bond formations. However, the analogous transformations of stabilized radicals from the corresponding acid precursors remain challenging owing to the strong preference towards single-electron oxidation to the stable carbocations. This work describes a general strategy for rapid access to various aliphatic and aromatic boronic esters by mild photoinduced decarboxylative borylation. Both aryl and alkyl radicals could be generated from the leaving group-assisted N-hydroxybenzimidoyl chloride esters, even α-CF3 substituted substrates could be activated for further elaboration.
FLUOROALKYLATING AGENT
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Paragraph 1341-1342, (2018/01/11)
Problem to be Solved It is intended to provide an industrially preferable fluoroalkylating agent and use thereof. Solution The present invention provides a fluoroalkylating agent represented by the general formula (1) wherein R1 is a C1 to C8 fluoroalkyl group; R2 and R3 are each independently a C1 to C12 alkyl group or the like; Y1 to Y4 are each independently a hydrogen atom, a halogen atom, or the like; and X? is a monovalent anion. A compound of the general formula (3): R4—S—R1 having an introduced C1 to C8 fluoroalkyl group is easily obtained by reacting a compound of the general formula (2): R4—S—Z wherein R4 is a hydrocarbon group or the like; and Z is a leaving group, with the compound of the general formula (1).
Nickel-Catalyzed Alkyl-Alkyl Cross-Couplings of Fluorinated Secondary Electrophiles: A General Approach to the Synthesis of Compounds having a Perfluoroalkyl Substituent
Liang, Yufan,Fu, Gregory C.
supporting information, p. 9047 - 9051 (2015/08/03)
Fluorinated organic molecules are of interest in fields ranging from medicinal chemistry to polymer science. Described herein is a mild, convenient, and versatile method for the synthesis of compounds bearing a perfluoroalkyl group attached to a tertiary carbon atom by using an alkyl-alkyl cross-coupling. A nickel catalyst derived from NiCl2 glyme and a pybox ligand achieves the coupling of a wide range of fluorinated alkyl halides with alkylzinc reagents at room temperature. A broad array of functional groups is compatible with the reaction conditions, and highly selective couplings can be achieved on the basis of differing levels of fluorination. A mechanistic investigation has established that the presence of 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) inhibits cross-coupling under these conditions and that a TEMPO-electrophile adduct can be isolated.
