1228150-91-1

Basic information

• Product Name: (E)-1,1,1-trifluoro-4-morpholino-4-phenyl-but-3-en-2-ol
• Synonyms: (E)-1,1,1-trifluoro-4-morpholino-4-phenyl-but-3-en-2-ol
• CAS NO: 1228150-91-1
• Molecular Weight: 287.282
• Mol File: 1228150-91-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-1,1,1-trifluoro-4-morpholino-4-phenyl-but-3-en-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1,1,1-trifluoro-4-morpholino-4-phenyl-but-3-en-2-ol(1228150-91-1)
• EPA Substance Registry System: (E)-1,1,1-trifluoro-4-morpholino-4-phenyl-but-3-en-2-ol(1228150-91-1)

Safety Data

• Hazardous Substances Data: 1228150-91-1(Hazardous Substances Data)

Upstream product

• 7196-01-2 4-(1-phenylvinyl)morpholine 
• 433-27-2 ethyl trifluoroacetaldehyde hemiacetal 

Downstream Products

• 1228150-94-4 1,1,1-trifluoro-4-morpholino-4-phenylbutan-2-ol 
• 101396-02-5 1-(β-phenylethyl)-2,2,2,-trifluoroethanol 
• 1524-15-8 4,4,4-trifluoro-3-hydroxy-1-phenylbutan-1-one 

Relevant articles and documents

Synthesis and hydrogenation of (E)-γ-aryl-γ-morpholino-α-trifluoromethylated allyl alcohols through the reaction of trifluoroacetaldehyde ethyl hemiacetal with enamines

Treatment of trifluoroacetaldehyde ethyl hemiacetal with enamines, derived from acetophenone derivatives, at room temperature gave (E)-1,1,1-trifluoro-4-morpholino-4-aryl-but-3-en-2-ols, which are intermediates for preparation of the β-trifluoromethylated aldol products, 4,4,4-trifluoro-3-hydroxy-1-aryl-butan-1-ones. The structure of the intermediate (E)-1,1,1-trifluoro-4-morpholino-4-(4-nitrophenyl)-but-3-en-2-ols could be assigned by 1H, 13C NMR, IR, and X-ray crystallography. Furthermore, hydrogenation and reductive deamination of the intermediate (E)-1,1,1-trifluoro-4-morpholino-4-aryl-but-3-en-2-ols with hydrogen in the presence of a catalytic amount (10 mol %) of palladium on carbon in trifluoroethanol proceeded smoothly at room temperature to give 1,1,1-trifluoro-4-aryl-2-butanols in good to excellent yields.