10167-35-8

Basic information

• Product Name: 3-PHENYLMETHYL-3,4-DIHYDRO-1,4-BENZODIAZEPIN-2,5-DIONE
• Synonyms: 3-PHENYLMETHYL-3,4-DIHYDRO-1,4-BENZODIAZEPIN-2,5-DIONE;3-Benzyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione
• CAS NO: 10167-35-8
• Molecular Formula: C₁₆H₁₄N₂O₂
• Molecular Weight: 266.29
• Product Categories: pharmacetical
• Mol File: 10167-35-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 275-278 °C
• Boiling Point: 577.7°Cat760mmHg
• Flash Point: 237.5°C
• Appearance: /
• Density: 1.225g/cm³
• Vapor Pressure: 2.42E-13mmHg at 25°C
• Refractive Index: 1.601
• PKA: 12.92±0.40(Predicted)
• CAS DataBase Reference: 3-PHENYLMETHYL-3,4-DIHYDRO-1,4-BENZODIAZEPIN-2,5-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PHENYLMETHYL-3,4-DIHYDRO-1,4-BENZODIAZEPIN-2,5-DIONE(10167-35-8)
• EPA Substance Registry System: 3-PHENYLMETHYL-3,4-DIHYDRO-1,4-BENZODIAZEPIN-2,5-DIONE(10167-35-8)

Safety Data

• Hazardous Substances Data: 10167-35-8(Hazardous Substances Data)

Usage

General Description

3-Phenylmethyl-3,4-dihydro-1,4-benzodiazepin-2,5-dione, also known as Flurazepam, is a chemical compound that belongs to the benzodiazepine class of drugs. It is commonly used as a sedative and hypnotic medication to treat insomnia and other sleep disorders. The compound acts by binding to specific receptors in the brain, enhancing the effects of a neurotransmitter called gamma-aminobutyric acid (GABA), which has a calming effect on the brain. Flurazepam is available in the form of oral tablets and is typically prescribed for short-term use due to its potential for dependence and tolerance development. It is important to use flurazepam under the guidance of a healthcare professional to avoid potential adverse effects and dependence.

InChI:InChI=1/C16H14N2O2/c19-15-12-8-4-5-9-13(12)17-16(20)14(18-15)10-11-6-2-1-3-7-11/h1-9,14H,10H2,(H,17,20)(H,18,19)

Upstream product

• 64-18-6 formic acid 
• 27262-04-0 2-(2-Nitro-benzoylamino)-3-phenyl-propionic acid methyl ester 
• 5619-07-8 methyl 2-amino-3-phenylpropanoate hydrochloride 
• 90-16-4 1,2,3-benzotriazin-4(3H)-one 
• 63-91-2 L-phenylalanine 
• 552-16-9 ortho-nitrobenzoic acid 
• 118-48-9 isatoic anhydride 
• 150-30-1 Phenylalanine 
• 68790-38-5 2-(tert-butyloxycarbonylamino)benzoic acid 

Downstream Products

• 58445-88-8 1-methyl-3-benzyl-3H-1(H),4(H)-benzodiazepin-2,5-dione 

Relevant articles and documents

New synthesis of 1,4 benzodiazepine-2,5-diones by means of HCl gas catalyst

A new synthesis of 1,4-benzodiazepinediones 4, particularly 1,4-dihydro1H-1,4-benzodiazepine-2,5-dione, 4c key intermediate of metabolites cyclopenin 9, cyclopenol 10, cyclopeptine 11 and dehydrocyclopeptide 12, was achieved by action of dry HCl gas in DM

A novel one step approach to the synthesis of 3H-1,4-benzodiazepin-(1H,4H)-2,5-diones from 1,2,3-benzotriazin-4-(3H)-one

1,2,3-Benzotriazin-4-(3H)-one(3) and its 6-chloro derivative (4) on thermal condensation with α-amino acids yielded 3H-1,4-benzodiazepin-(1H,4H)-2,5-diones(7-12) in moderate to good yield. The cyclocondensation is believed to proceed through the formation of an iminoketene intermediate (5).

Simple synthesis, structure and ab initio study of 1,4-benzodiazepine-2,5- diones

A simple procedure for the synthesis of pyrido[2,1-c][1,4] benzodiazepine-6,12-dione (1) and 1,4-benzodiazepine-2,5-diones (2a-2d), using microwave irradiation and/or conventional heating is reported. The configuration of 1 was determined by single-crysta