1041926-38-8

Basic information

• Product Name: C₁₉H₁₈N₂O₃
• Synonyms: C₁₉H₁₈N₂O₃
• CAS NO: 1041926-38-8
• Molecular Weight: 322.364
• Mol File: 1041926-38-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₉H₁₈N₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₁₈N₂O₃(1041926-38-8)
• EPA Substance Registry System: C₁₉H₁₈N₂O₃(1041926-38-8)

Safety Data

• Hazardous Substances Data: 1041926-38-8(Hazardous Substances Data)

Upstream product

• 4224-00-4 3-methyl-5,5-diphenyl-imidazolidine-2,4-dione 
• 106-89-8 epichlorohydrin 

Downstream Products

• 1041926-26-4 1-(2-hydroxy-3-(4-(pyridin-2-yl)piperazin-1-yl)propyl)-3-methyl-5,5-diphenylimidazolidine-2,4-dione 
• 1041926-23-1 1-(2-hydroxy-3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)-3-methyl-5,5-diphenylimidazolidine-2,4-dione 
• 1041926-24-2 1-(2-hydroxy-3-(4-(2-ethoxyphenyl)piperazin-1-yl)propyl)-3-methyl-5,5-diphenylimidazolidine-2,4-dione 
• 1041926-25-3 1-(3-(4-(furan-2-carbonyl)piperazin-1-yl)-2-hydroxypropyl)-3-methyl-5,5-diphenylimidazolidine-2,4-dione 
• 1350707-24-2 1-(3-methyl-2,4-dioxo-5,5-diphenylimidazolidin-1-yl)-3-(4-phenylpiperazin-1-yl)propan-2-yl acetate 
• 1350706-17-0 1-[2-hydroxy-3-(4-phenylpiperazin-1-yl)-propyl]-2,4-dioxo-3-methyl-5,5-diphenylimidazolidine 
• 1370333-43-9 1-[3-(4-(2-fluorophenyl)-piperazin-1-yl)-2-hydroxypropyl]-3-methyl-2,4-dioxo-5,5-diphenylimidazolidine hydrochloride 
• 1255933-41-5 1-[3-(4-(2-fluorophenyl)-piperazin-1-yl)-2-hydroxypropyl]-3-methyl-2,4-dioxo-5,5-diphenylimidazolidine 
• 1370333-42-8 1-[3-(4-(2-chlorophenyl)-piperazin-1-yl)-2-hydroxypropyl]-3-methyl-2,4-dioxo-5,5-diphenylimidazolidine hydrochloride 
• 1370333-33-7 1-[3-(4-(2-chlorophenyl)-piperazin-1-yl)-2-hydroxypropyl]-3-methyl-2,4-dioxo-5,5-diphenylimidazolidine 
• 1370333-41-7 1-[2-hydroxy-3-(4-phenylpiperazin-1-yl)-propyl]-2,4-dioxo-3-methyl-5,5-diphenylimidazolidine hydrochloride 

Relevant articles and documents

Amine-alkyl derivatives of hydantoin: New tool to combat resistant bacteria

A series of new 5,5-diphenylhydantoin derivatives with various amine-alkyl terminal fragments at N1-position were synthesized. Then a series of twenty-eight compounds with the same hydantoin scaffold were evaluated for their potency to combat bacterial MultiDrug Resistance (MDR). Intrinsic antibacterial activities were first evaluated. As these compounds showed no direct activity on bacteria, their influence on minimal inhibitory concentration (MIC) of nalidixic acid was tested in two strains of Enterobacter aerogenes: the reference-strain ATCC-13048 and the CM-64 strain which over-produces AcrAB-TolC efflux pump. The compounds showed moderate- or low- anti-MDR properties. According to SAR-studies, hit compounds containing 2-methoxyphenylpiperazine at N1-terminal fragment and methylcarboxyl acid one at N3-position of hydantoin have been identified for further microbiological studies and pharmacomodulations to develop efflux pump inhibitors.