4224-00-4

Basic information

• Product Name: 3-Methyl-5,5-diphenylhydantoin
• Synonyms: 3-Methyl-5,5-diphenylhydantoin;3-Methyl-5,5-diphenylimidazolidine-2,4-dione;Hydotin;Melantoin;Methylphenytoin
• CAS NO: 4224-00-4
• Molecular Formula: C₁₆H₁₄N₂O₂
• Molecular Weight: 266.2946
• Mol File: 4224-00-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.235g/cm³
• Refractive Index: 1.607
• CAS DataBase Reference: 3-Methyl-5,5-diphenylhydantoin(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methyl-5,5-diphenylhydantoin(4224-00-4)
• EPA Substance Registry System: 3-Methyl-5,5-diphenylhydantoin(4224-00-4)

Safety Data

• Hazardous Substances Data: 4224-00-4(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 13, p. 3921, 1972 DOI: 10.1016/S0040-4039(01)94197-8

InChI:InChI=1/C16H14N2O2/c1-18-14(19)16(17-15(18)20,12-8-4-2-5-9-12)13-10-6-3-7-11-13/h2-11H,1H3,(H,17,20)

Upstream product

• 24133-92-4 2,3-dimethyl-5,5-diphenyl-3,5-dihydro-imidazol-4-one 
• 1066-30-4 chromium(lll) acetate 
• 134-81-6 benzil 
• 598-50-5 N-Methylurea 
• 57-41-0 phenythoin 
• 74-88-4 methyl iodide 
• 74-87-3 methylene chloride 
• 74-83-9 methyl bromide 
• 78451-65-7 S-ethyl-5,5'-diphenyl-2-thiohydantoin 
• 22544-70-3 5,5-Diphenyl-2-methylmercapto-4-oxo-imidazoline 
• 21083-47-6 5,5-diphenyl-2-thioxoimidazolidin-4-one 
• 6456-01-5 1,3-dimethyl-5,5-diphenylhydantoin 
• 64-19-7 acetic acid 
• 21083-48-7 3-methyl-5,5-diphenyl-2-thioxoimidazolidin-4-one 

Downstream Products

• 16459-61-3 1-acetyl-3-methyl-5,5-diphenyl-imidazolidine-2,4-dione 
• 16116-38-4 3-Methyl-5,5-diphenyl-dithiohydantoin 
• 151412-74-7 1-chloro-5,5-diphenyl-3-methylhydantoin 
• 74-89-5 methylamine 
• 91-00-9 Benzhydrylamine 
• 3653-24-5 1-methyl-4,4-diphenyl-5-thioxo-imidazolidin-2-one 
• 22544-78-1 1-Methyl-2-methylmercapto-4.4-diphenyl-2-imidazolin-5-thion 
• 16116-32-8 1,3-dimethyl-4,4-diphenyl-5-thioxo-imidazolidin-2-one 
• 1350706-10-3 3-methyl-5,5-diphenyl-1-(5-(4-phenylpiperazin-1-yl)pentyl)imidazolidine-2,4-dione 
• 1608154-16-0 3-methyl-5,5-diphenyl-1-(5-(4-phenylpiperazin-1-yl)pentyl)imidazolidine-2,4-dione hydrochloride 
• 1370333-48-4 1-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-3-methyl-5,5-diphenylimidazolidine-2,4-dione hydrochloride 
• 1370333-47-3 1-(3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)-3-methyl-5,5-diphenylimidazolidine-2,4-dione hydrochloride 
• 1370333-39-3 1-(4-bromobutyl)-3-methyl-5,5-diphenylimidazolidine-2,4-dione 
• 1041926-38-8 C₁₉H₁₈N₂O₃ 

Relevant articles and documents

New aspects of reactions of methyl (thio)ureas with benzil

New pathways of reaction between 1-methylthiourea or 1-methylurea and benzil bring about new derivatives of (2S*,3aR*,6aS*)-perhydro-3aH-[1,3]dioxolo[4,5-d]imidazole and racemic (4S*,5R*)-4-alkoxy-5-hydroxy-1-methyl-4,5-diphenylimidazolidine-2-thiones. So

Chitosan decorated Fe3O4 nanoparticles as a magnetic catalyst in the synthesis of phenytoin derivatives

In the present work, Fe3O4 nanoparticles were synthesized by the chemical coprecipitation process. Subsequently, the synthesized nanoparticles were modified with chitosan by a simple method and characterized by X-ray diffractometry (XRD), Fourier transform infrared spectrophotometry (FT-IR), vibrating sample magnetometry (VSM), scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX). Then, phenytoin derivatives were catalyzed by magnetic Fe3O4-chitosan nanoparticles. Fe3O4-chitosan nanoparticles were found to be a recoverable organocatalyst for the efficient synthesis of 5,5-diphenylhydantoins and 5,5-diphenyl-2-thiohydantoins from substituted benzils and urea or thiourea derivatives. The nanocatalyst could be recovered easily under a magnetic field for reuse, and considerable loss of its catalytic activity was not observed after reuse in seven consecutive runs. This journal is

Structure-activity relationships of 3-substituted-5,5-diphenylhydantoins as potential antiproliferative and antimicrobial agents

A series of twelve 3-substituted-5,5-diphenylhydantoins was synthesized, including some whose anticonvulsant activities have already been reported in the literature. Their antiproliferative activities against HCT-116 human colon carcinoma cells were evalu