104600-21-7

Basic information

• Product Name: methyl 3-cyclopropylamino-2-(2,4-dichloro-5-fluorobenzoyl)acrylate
• Synonyms: methyl 3-cyclopropylamino-2-(2,4-dichloro-5-fluorobenzoyl)acrylate
• CAS NO: 104600-21-7
• Molecular Weight: 332.159
• Mol File: 104600-21-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl 3-cyclopropylamino-2-(2,4-dichloro-5-fluorobenzoyl)acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-cyclopropylamino-2-(2,4-dichloro-5-fluorobenzoyl)acrylate(104600-21-7)
• EPA Substance Registry System: methyl 3-cyclopropylamino-2-(2,4-dichloro-5-fluorobenzoyl)acrylate(104600-21-7)

Safety Data

• Hazardous Substances Data: 104600-21-7(Hazardous Substances Data)

Upstream product

• 90087-77-7 methyl 3-pyrrolidinoacrylate 
• 86393-34-2 2,4-dichloro-5-fluorobenzoyl chloride 
• 704-10-9 2,4-dichloro-5-fluoroacetophenone 
• 68-12-2 N,N-dimethyl-formamide 
• 616-38-6 carbonic acid dimethyl ester 
• 77-78-1 dimethyl sulfate 
• 765-30-0 Cyclopropylamine 

Downstream Products

• 85721-33-1 ciprofloxacin 
• 86393-33-1 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid 

Relevant articles and documents

Synthesis of amide derivatives of quinolone and their antimicrobial studies

A series of 1 -cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[chloro/1 -piperazinyl/4-methyl-1-piperazinyl/4-ethyl-1-piperazinyl/ 4-hydroxyethyl-1- piperazinyl/imidazolyl/morpholinyl]-3[N-(substituted phenyl amino) carbonyl]quinoline 5-11a-j have been prepared by using substituted arylamine at C-3 position and 1-piperazine/4-methyl-1-piperazine/4-ethyl-1-piperazine/4- hydroxyethyl-1-piperazine/imidazole/morpholine at C-7 position of newly synthesized quinolone 3. Biological profile like antibacterial activity against four different strain viz. S. aureus and B. subtilis (gram-positive bacteria) and E. coli and P. aeruginosa (gram-negative bacteria) and C. albicans (fungi) by cup plate method have been studied.

3-amino-2-benzoylacrylic acid derivatives

Novel 3-amino-2-benzoyl-acrylic acid derivatives of the formula STR1 in which R1 represents the nitrile group, an ester group --COOR4 or carboxamide group STR2 R4 denoting C1 -C6 -alkyl, and R5 and R6 representing hydrogen or C1 -C3 -alkyl or phenyl, R2 and R3, which can be identical or different, represent a C1 -C6 -alkyl radical and, furthermore, can form, together with the nitrogen atom to which they are bonded, a 5- or 6-membered heterocyclic ring which can additionally contain as ring member the atoms or groups --O--, --S--, --SO-- or --SO2 --, X represents halogen, X1 denotes hydrogen, methyl, nitro or halogen, X2 denotes halogen or methyl, and X3 denotes hydrogen or halogen, are prepared by reacting STR3 The products can be converted into known antibacterials.