704-10-9Relevant articles and documents
Preparation method of 2, 4-dichloro-5-fluoroacetophenone
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Paragraph 0015-0016; 0017; 0035-0037, (2021/08/14)
The invention provides a preparation method of 2, 4-dichloro-5-fluoroacetophenone. The method comprises the following steps: by taking 2, 4-dichlorofluorobenzene as a raw material, carrying out Friedel-Crafts reaction on 2, 4-dichlorofluorobenzene and vinylidene chloride in the presence of anhydrous aluminum chloride and protonic acid at the same time to generate 1-(1, 1-dichloroethyl)-2, 4-dichloro-5-fluoroacetophenone benzene, carrying out hydrolysis reaction on the intermediate product under the catalysis of Lewis acid to generate 2, 4-dichloro-5-fluoroacetophenone and hydrogen chloride, adding a proper amount of water for layering after the reaction is finished, and rectifying an organic layer to obtain the product. According to the method, the cost of raw materials and auxiliary materials is greatly reduced, the post-treatment pressure is relieved, the yield can reach 85% or above, and the method belongs to the technical field of organic chemical industry.
ANTIVIRAL AND ANTIMICROBIAL COMPOUNDS
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Paragraph 0120; 0121, (2014/03/25)
Disclosed are guanidine and biguanidine derivatives which have anti-viral and antibacterial activity. Also disclosed are pharmaceutical compositions containing such compounds as an active ingredient, and anti-viral and anti-bacterial methods utilizing such compounds. Methods of treating infections using the guanidine and biguanidine derivatives are also disclosed.
A novel approach to Finafloxacin hydrochloride (BAY35-3377)
Hong, Jian,Zhang, Zonghua,Lei, Huoxing,Cheng, Haiying,Hu, Yufang,Yang, Wanliang,Liang, Yinglin,Das, Debasis,Chen, Shu-Hui,Li, Ge
body text, p. 2525 - 2528 (2009/09/06)
Finafloxacin hydrochloride, an important clinical compound was synthesized by a novel synthetic approach. An active intermediate ethyl 7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate 19 was prepared by a new route. The chiral (S,S′)-N-Boc 10 was derived from protected pyrrolidine and the absolute stereochemistry was established by X-ray analysis.