108981-92-6

Basic information

• Product Name: 2-(naphthalene-1-yl)benzoic acid
• Synonyms: 2-(naphthalene-1-yl)benzoic acid
• CAS NO: 108981-92-6
• Molecular Weight: 248.281
• Mol File: 108981-92-6.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 2-(naphthalene-1-yl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(naphthalene-1-yl)benzoic acid(108981-92-6)
• EPA Substance Registry System: 2-(naphthalene-1-yl)benzoic acid(108981-92-6)

Safety Data

• Hazardous Substances Data: 108981-92-6(Hazardous Substances Data)

Usage

General Description

2-(naphthalene-1-yl)benzoic acid is a chemical compound with the molecular formula C17H12O2. It is a derivative of benzoic acid, with a naphthalene group attached to the benzene ring. 2-(naphthalene-1-yl)benzoic acid is often used in the pharmaceutical industry as a building block for the synthesis of various drugs and pharmaceuticals. It has also been studied for its potential anti-inflammatory and antioxidant properties. Additionally, it is used as a chemical intermediate in the production of dyes, pigments, and other organic compounds. Overall, 2-(naphthalene-1-yl)benzoic acid has a range of industrial and medicinal applications due to its unique chemical structure and properties.

Upstream product

• 90-14-2 1-Iodonaphthalene 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 6051-98-5 7H-benzo[c]fluoren-7-one 
• 93655-02-8 methyl 2-(naphthalen-1-yl)benzoate 
• 131-62-4 1-hydroxy-1,2-benzodioxol-3-(1H)-one 
• 13922-41-3 1-Naphthylboronic acid 
• 954137-87-2 2-(1-naphthyl)benzoic acid ethyl ester 
• 392-83-6 o-trifluoromethylphenyl bromide 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 88-65-3 2-bromobenzoic-acid 
• 90-11-9 1-Bromonaphthalene 

Downstream Products

• 82-05-3 7H-benz[d,e]anthracene-7-one 
• 6051-98-5 7H-benzo[c]fluoren-7-one 

Relevant articles and documents

Aluminum oxide mediated C-F bond activation in trifluoromethylated arenes

Thermally activated γ-aluminium oxide was found to be very effective for C-F bond activation in trifluoromethylated arenes. Depending on the activation degree the respective arenes can be converted either to cyclic ketones or to the respective carboxylic acids with good to excellent yields.

Room-temperature cobalt-catalyzed arylation of aromatic acids: overriding the ortho-selectivity via the oxidative assembly of carboxylate and aryl titanate reagents using oxygen

A room temperature phosphine or NHC ligand-free cobalt-catalyzed arylation of (hetero)aromatic acids has been developed. It involves an oxidative cross-coupling between carboxylate and aryl titanate reagents using oxygen as an oxidant, and the arylation at the position ortho, meta and para to the carboxylic acid group could all be achieved. As application, various (hetero)aromatic acids including xenalipin, tafamidis and the key intermediate for a cardioprotective compound have been efficiently synthesized.

Synthesis of seven-membered lactones by regioselective and stereoselective iodolactonization of electron-deficient olefins

A regio- A nd stereoselective iodolactonization of internal electron-deficient olefinic acids has been reported, which provides a straightforward access to a series of multi-functionalized seven-membered lactones containing two consecutive chiral centers. The ester substituents on the olefins played a key role in achieving high regioselectivity. This result was proved through experiments and DFT calculations.

Exploration of Biaryl Carboxylic Acids as Proton Shuttles for the Selective Functionalization of Indole C-H Bonds

A survey of diversely substituted 2-arylbenzoic acids were synthesized and tested for use as proton shuttle in the direct arylation of indoles with bromobenzenes. It was found that 3-ethoxy-2-phenylbenzoic acid gives superior yield and selectivity for this class of substrates.