6051-98-5 Usage
Description
BENZO[C]FLUOREN-7-ONE is a chemical compound that serves as an intermediate in the synthesis of 7H-Benzo[c]fluorene, a polycyclic aromatic hydrocarbon (PAH) with mutagenic activity. It is known for its potential role in forming DNA adducts and its association with coal tar, which has implications for its biological activity and potential health risks.
Uses
Used in Chemical Synthesis:
BENZO[C]FLUOREN-7-ONE is used as a chemical intermediate for the synthesis of 7H-Benzo[c]fluorene, a compound with mutagenic properties and potential carcinogenic effects. Its role in the formation of DNA adducts makes it a compound of interest in the study of chemical carcinogenesis and mutagenicity.
Used in Research and Development:
In the field of research and development, BENZO[C]FLUOREN-7-ONE is utilized to investigate the mechanisms of DNA adduct formation and the potential carcinogenic effects of PAHs, such as 7H-Benzo[c]fluorene. This knowledge is crucial for understanding the molecular basis of cancer and developing strategies for prevention and treatment.
Used in Environmental and Occupational Health:
BENZO[C]FLUOREN-7-ONE is relevant in environmental and occupational health studies due to its presence in coal tar, a substance used in various industrial processes. Understanding the exposure risks and health implications associated with BENZO[C]FLUOREN-7-ONE and its derivatives can inform safety regulations and protective measures for workers and the general population.
Used in Pharmaceutical Development:
Although BENZO[C]FLUOREN-7-ONE itself may have mutagenic and carcinogenic properties, understanding its chemical structure and biological activity can contribute to the development of pharmaceuticals that target specific pathways involved in cancer and other diseases. This knowledge can be applied to design drugs with improved efficacy and reduced side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 6051-98-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,0,5 and 1 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 6051-98:
(6*6)+(5*0)+(4*5)+(3*1)+(2*9)+(1*8)=85
85 % 10 = 5
So 6051-98-5 is a valid CAS Registry Number.
InChI:InChI=1/C17H10O/c18-17-14-8-4-3-7-13(14)16-12-6-2-1-5-11(12)9-10-15(16)17/h1-10H
6051-98-5Relevant articles and documents
Aluminum oxide mediated C-F bond activation in trifluoromethylated arenes
Papaianina,Amsharov
supporting information, p. 1505 - 1508 (2016/01/25)
Thermally activated γ-aluminium oxide was found to be very effective for C-F bond activation in trifluoromethylated arenes. Depending on the activation degree the respective arenes can be converted either to cyclic ketones or to the respective carboxylic acids with good to excellent yields.
Synthesis of benzo[c]fluorenone through a one-pot cascade reaction using inden-1-one derivatives
Zheng, Shuyan,Tan, Hongsheng,Zhang, Xiaoguang,Yu, Chunhui,Shen, Zhengwu
supporting information, p. 975 - 978 (2014/02/14)
A novel one-pot thermal cycloaddition of two indenones followed by a decarbonylation and dehydrogenation cascade afforded benzo[c]fluorenones regioselectively. Various substituted indenone derivatives were converted into their corresponding benzo[c]fluorenones in good to excellent yields.
Cross dehydrogenative coupling via base-promoted homolytic aromatic substitution (BHAS): Synthesis of fluorenones and xanthones
Wertz, Sebastian,Leifert, Dirk,Studer, Armido
, p. 928 - 931 (2013/03/28)
Cross dehydrogenative coupling reactions occurring via base-promoted homolytic aromatic substitutions (BHASs) are reported. Fluorenones and xanthones are readily prepared via CDC starting with readily available ortho-formyl biphenyls and ortho-formyl biphenylethers, respectively. The commercially available and cheap tBuOOH is used as an oxidant. Initiation of the radical chain reaction is best achieved with small amounts of FeCp2 (0.1 or 1 mol %).
