1126856-38-9

Basic information

• Product Name: methyl 4-(methoxy-d₃)benzoate
• Synonyms: methyl 4-(methoxy-d₃)benzoate
• CAS NO: 1126856-38-9
• Molecular Weight: 169.153
• Mol File: 1126856-38-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: methyl 4-(methoxy-d₃)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(methoxy-d₃)benzoate(1126856-38-9)
• EPA Substance Registry System: methyl 4-(methoxy-d₃)benzoate(1126856-38-9)

Safety Data

• Hazardous Substances Data: 1126856-38-9(Hazardous Substances Data)

Upstream product

• 865-50-9 iodomethane-d3 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 23726-00-3 <²H9>trimethylsulphoxonium iodide 
• 811-98-3 d⁽⁴⁾-methanol 
• 619-42-1 4-methoxycarbonylphenyl bromide 

Downstream Products

• 27914-54-1 4-(methoxy-d₃)benzoic acid 
• 342611-03-4 C₈H₄⁽²⁾H₄O₂ 

Relevant articles and documents

Trideuteromethylation Enabled by a Sulfoxonium Metathesis Reaction

A conceptually novel sulfoxonium metathesis reaction between TMSOI and cost-effective DMSO-d6 is developed for the efficient generation of a new trideuteromethylation reagent TDMSOI. The new reagent TDMSOI is produced highly efficiently by simply heating a mixture of TMSOI and DMSO-d6 and directly used for subsequent trideuteromethylation in a "one-pot" operation. The preparative power of the new versatile reagent and the "one-pot" protocol is demonstrated by its use to install the ?CD3 moiety into broad functionalities including phenols, thiophenols, acidic amines, and enolizable methylene units in high yield and at a useful level of deuteration (>87% D).

Rhodium-catalyzed tunable oxidative cyclization toward the selective synthesis of α-pyrones and furans

The rhodium(iii)-catalyzed tunable oxidative cyclization of readily available N-tosylacrylamides and diazo compounds is presented, which offers a novel method for the selective construction of fully substituted α-pyrones and furans in a regiospecific manner by employing the acylsulfonamide group as a versatile in situ removable directing group.

Synthesis of 14C- and13C/2H-labeled SGLT inhibitors AVE2268 and AVE8887

Isotopically labeled analogues of two structurally very similar SGLT inhibitors AVE2268 (1a) and AVE8887 (1b) have been synthesized by various routes. The radioactive labeled [14C]-AVE2268 was prepared in 5 steps including a Friedel-Crafts acylation as the key step for the 14C-label introduction. For [14C]-AVE8887 the same synthetic approach was not successful and therefore an alternative thiophene metalation/Weinreb amide sequence was developed. This pathway was also applied to obtain stable isotopically labeled analogs of both AVE2268 and AVE8887. Copyright r 2010 John Wiley & Sons, Ltd.