1173177-23-5

Basic information

• Product Name: C₂₃H₂₈ClFN₄O₃
• Synonyms: C₂₃H₂₈ClFN₄O₃
• CAS NO: 1173177-23-5
• Molecular Weight: 462.952
• Mol File: 1173177-23-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₈ClFN₄O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₈ClFN₄O₃(1173177-23-5)
• EPA Substance Registry System: C₂₃H₂₈ClFN₄O₃(1173177-23-5)

Safety Data

• Hazardous Substances Data: 1173177-23-5(Hazardous Substances Data)

Upstream product

• 912468-80-5 1-methyl-1H-imidazole-4-carbonyl chloride hydrochloride 
• 1173177-20-2 C₁₈H₂₄ClFN₂O₂ 
• 41716-18-1 1-methylimidazole-4-carboxylic acid 
• 419572-18-2 (1R,5S,6r)-tert-butyl 6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate 
• 187681-87-4 (1R,5S,6s)-2,4-dioxo-3-oxabicyclo[3.1.0]hexane-6-carboxylic acid 
• 1366657-90-0 (1R,5S,6r)-3-benzyl-2,4-dioxo-3-azabicyclo[3.1.0]hexane-6-carboxylic acid 
• 134575-05-6 ethyl 5-benzyl-4,6-dioxo-1,3a,4,5,6,6a-hexahydropyrrolo[3,4-c]pyrazole-3-carboxylate 
• 705-35-1 trans,meso-1,2,3-cyclopropanetricarboxylic acid 
• 13949-99-0 trans,meso-cyclopropanetricarboxylic acid triethyl ester 
• 134575-13-6 (1α,5α,6α)-6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane 
• 134575-07-8 (1α,5α,6α)-6-hydroxymethyl-3-benzyl-3-aza-bicyclo[3.1.0]hexane 
• 134575-06-7 ethyl (1α,5α,6α)-3-benzyl-3-azabicyclo[3.1.0]hexane-2,4-dione-6-carboxylate 

Downstream Products

• 1173239-42-3 1-methyl-1H-imidazole-4-carboxylic acid (3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-chloro-4-fluoro-benzyl)-amide 
• 1173239-39-8 1-methyl-1H-imidazole-4-carboxylic acid (3-chloro-4-fluoro-benzyl)-(3-methyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide 

Relevant articles and documents

The discovery of a structurally novel class of inhibitors of the type 1 glycine transporter

The type 1 glycine transporter plays an important in regulating homeostatic glycine levels in the brain that are relevant to the activation of the NMDA receptor by the excitatory neurotransmitter glutamate. We describe herein the structure-activity relationships (SAR) of a structurally novel class of GlyT1 inhibitors following on a lead derived from high throughput screening, which shows good selectivity for GlyT1 and potent activity in elevating CSF levels of glycine.