13949-99-0

Basic information

• Product Name: triethyl(r)-cyclopropane-1,2,3-tricarboxylate
• Synonyms: triethyl(r)-cyclopropane-1,2,3-tricarboxylate;trans,meso-cyclopropanetricarboxylic acid triethyl ester
• CAS NO: 13949-99-0
• Molecular Formula: C₁₂H₁₈O₆
• Molecular Weight: 255.2439
• Mol File: 13949-99-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: triethyl(r)-cyclopropane-1,2,3-tricarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: triethyl(r)-cyclopropane-1,2,3-tricarboxylate(13949-99-0)
• EPA Substance Registry System: triethyl(r)-cyclopropane-1,2,3-tricarboxylate(13949-99-0)

Safety Data

• Hazardous Substances Data: 13949-99-0(Hazardous Substances Data)

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 623-91-6 diethyl Fumarate 
• 318990-47-5 ethyl pentamethylene-λ⁴-sulfanylideneacetate 
• 105-39-5 chloroacetic acid ethyl ester 
• 1331786-73-2 ethyl 3-(4-nitrophenyl)-2,4-dioxo-3-azabicyclo[3.1.0]hexane-6-carboxylate 
• 1415110-31-4 diethyl 3-[(4-nitrophenyl)carbamoyl]cyclopropane-1,2-dicarboxylate 
• 64-17-5 ethanol 
• 1415110-33-6 diethyl 3-[(tert-butoxycarbonyl)(4-nitrophenyl)-carbamoyl]cyclopropane-1,2-dicarboxylate 
• 1520-50-9 but-2-enedioic acid diethyl ester 

Downstream Products

• 5575-42-8 trans-1,2,3-Tris(p-toluolsulfonylmethyl)cyclopropan 
• 3227-90-5 Trimethylen-cyclopropan 
• 1173177-20-2 C₁₈H₂₄ClFN₂O₂ 
• 1173177-23-5 C₂₃H₂₈ClFN₄O₃ 
• 1173239-42-3 1-methyl-1H-imidazole-4-carboxylic acid (3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-chloro-4-fluoro-benzyl)-amide 
• 419572-18-2 (1R,5S,6r)-tert-butyl 6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate 
• 1173239-39-8 1-methyl-1H-imidazole-4-carboxylic acid (3-chloro-4-fluoro-benzyl)-(3-methyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide 
• 187681-87-4 (1R,5S,6s)-2,4-dioxo-3-oxabicyclo[3.1.0]hexane-6-carboxylic acid 
• 1366657-90-0 (1R,5S,6r)-3-benzyl-2,4-dioxo-3-azabicyclo[3.1.0]hexane-6-carboxylic acid 
• 927679-54-7 (1α,5α,6α)-3-(tert-butoxycarbonyl)-3-azabicyclo[3.1.0]hexane-6-carboxylic acid 
• 1330003-88-7 1-(3-chloro-4-fluorophenyl)-N-{[(1R,5S,6s)-3-methyl-3-azabicyclo[3.1.0]hex-6-yl](2H₁)methyl}(13C,2H₂)methan(15N)amine 
• 705-35-1 trans,meso-1,2,3-cyclopropanetricarboxylic acid 
• 134575-13-6 (1α,5α,6α)-6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane 
• 134575-07-8 (1α,5α,6α)-6-hydroxymethyl-3-benzyl-3-aza-bicyclo[3.1.0]hexane 

Relevant articles and documents

Enantiodivergent syntheses of (-)- and (+)-dysibetaine CPa and N-desmethyl analog

The first total syntheses of (-)-dysibetaine CPa and the antipode have been achieved using enantioselective solvolysis of meso-cyclic anhydride mediated by quinine derivative as an organocatalyst. The synthesis features a demonstration of an enantiodiverg

Simple large-scale preparation of 1,2,3-tris-acceptor substituted cyclopropanes

Triethyl (1α,2α,3β)cyclopropane-1,2,3-tricarboxylate (3aa), as well as diethyl (4ab) and dimethyl (1α,2β,3α)-1-acetylcyclopropane-2,3-dicarboxylate (4bb) have been prepared on a scale of up to 60 g by Michael initiated ring-closure (MIRC) cyclopropanation of dialkyl fumarates 1a,b with ethyl chloroacetate (2a) and chloroacetone (2b) in 62%, 51% and 56% yield, respectively. For the success of the new procedure it is essential to slowly add (within 5-7 h) the mixture of compounds 1 and 2 to a vigorously stirred suspension of K2CO3 in DMF in the presence of benzyltriethylammonium chloride.