1193-65-3Relevant articles and documents
Preparation method of optical activity 3-quinuclidinol
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Paragraph 0013; 0014, (2018/04/03)
The invention relates to an intermediate synthesis method, belongs to the field of organic synthesis, and particularly relates to a preparation method of optical activity 3-quinuclidinol with the advantages that the operation is simple and convenient, the cost is low, and the method is suitable for industrial production. An intermediate of 3-quinuclidinol is obtained by using 4-nipecotic acid as astarting material through esterification, nucleophilic substitution, Dieckmann condensation, decarboxylation, salification, reduction, acetylization, chemical resolution and the like. The reaction formula is shown in the description.
A process for producing 3-quinuclidinone hydrochloride by oxidation of unwanted isomer 3-S-quinuclidinol
Chavakula, Ramadas,Rao, Mutyala Narayana,Rao, Chennupati Srinivasa
, p. 261 - 262 (2013/06/05)
An industrially efficient method was developed synthetic process for the preparation of 3-quinuclidinone HCl by recycling of 3-S-quinuclidinol in one step sequence of oxidation process. Oxidation of secondary alcohol of 3-S-quinuclidinol which utilises complexes of a sulfide such as dimethyl sulfide with N-chlorosuccinimide to give target compound in high yield.
SYNTHESIS AND PROPERTIES OF 2-ETHOXYCARBONYL-3-AMINO-2,3-DEHYDROQUINUCLIDINE
Vorob'eva, V. Ya.,Mikhlina, E. E.,Turchin, K. F.,Yakhontov, L. N.
, p. 782 - 785 (2007/10/02)
The reduction of 2-ethoxycarbonyl-3-oxoquinuclidine oxime hydrochloride leads to 2-ethoxycarbonyl-3-amino-2,3-dehydroquinuclidine, from which pyrimidoquinuclidine derivatives were obtained by reaction with formamide, methyl isocyanate, and phenyl isocyanate.It is shown that 7-hydroxypyrazoloquinuclidine is formed in the reaction of 2-ethoxycarbonyl-3-acetamido-2,3-dehydroquinuclidine with hydrazine hydrate.