1196-69-6Relevant articles and documents
Palladium-Catalyzed Reductive Carbonylation of (Hetero) Aryl Halides and Triflates Using Cobalt Carbonyl as CO Source
Dogga, Bhushanarao,Joseph, Jayan T.,Kumar, C. S. Ananda
supporting information, p. 309 - 313 (2020/12/23)
An efficient protocol for the reductive carbonylation of (hetero) aryl halides and triflates under CO gas-free conditions using Pd/Co2(CO)8 and triethylsilane has been developed. The mild reaction conditions, enhanced chemoselectivity and, easy access to heterocyclic and vinyl carboxaldehydes highlights its importance in organic synthesis.
Synthesis and Evaluation of Indole-Based Autoinducers on Quorum Sensing in Vibrio cholerae
Holoidovsky, Lara,Meijler, Michael M.
, p. 572 - 576 (2020/04/30)
Vibrio cholerae (V. cholerae) uses the autoinducer CAI-1 (cholera autoinducer 1) and several linked quorum sensing systems in order to efficiently sense its ever-changing environment and optimally coordinate population-wide gene expression. Indole has been reported as an important signal that is sensed by V. cholerae, and here, we report the synthesis and evaluation of a focused library of synthetic indole-CAI-1 derivatives as tools to probe quorum sensing (QS) in this human pathogen. Our results show interesting and diverging effects for several conjugates, as compared to CAI-1, on virulence factor production and biofilm formation.
Synthesis method of 5-formylindole
-
Paragraph 0011; 0016-0023, (2020/02/10)
The invention discloses a synthesis method of formylindole. The synthesis method comprises the following processing steps: S1, dissolving the raw material indole in a solvent at room temperature, carrying out heating to 35-45 DEG C, and completely dissolving the raw material; and S2, slowly adding a catalyst into a mixed solvent of indole and ethyl formate, carrying out refluxing at 45-55 DEG C for 5-48 h, and performing cooling, crystallizing and filtering to obtain 5-formylindole, wherein the solvent used in the step S1 is one or more selected from the group consisting of methyl formate, ethyl formate, propyl formate and butyl formate, and the use amount of the solvent in the step S1 is 4-10 times the mass of indole. The method is mild in reaction, simple to operate, high in final product yield and good in quality.