946077-08-3

Basic information

• Product Name: (1-methyl-1H-indol-5-yl)-(3,4,5-trimethoxyphenyl)-methanone
• Synonyms: (1-methyl-1H-indol-5-yl)-(3,4,5-trimethoxyphenyl)-methanone
• CAS NO: 946077-08-3
• Molecular Weight: 325.364
• Mol File: 946077-08-3.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: (1-methyl-1H-indol-5-yl)-(3,4,5-trimethoxyphenyl)-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (1-methyl-1H-indol-5-yl)-(3,4,5-trimethoxyphenyl)-methanone(946077-08-3)
• EPA Substance Registry System: (1-methyl-1H-indol-5-yl)-(3,4,5-trimethoxyphenyl)-methanone(946077-08-3)

Safety Data

• Hazardous Substances Data: 946077-08-3(Hazardous Substances Data)

Usage

Description

(1-methyl-1H-indol-5-yl)-(3,4,5-trimethoxyphenyl)-methanone is a complex synthetic chemical compound characterized by the presence of an indole ring, a trimethoxyphenyl group, and a methanone functional group. It is not a naturally occurring substance and is primarily utilized in research and pharmaceutical contexts. While its specific applications and effects are not extensively documented, the compound may exhibit biological activity that warrants further investigation and testing to elucidate its properties and potential uses.

Uses

Used in Research Applications:
(1-methyl-1H-indol-5-yl)-(3,4,5-trimethoxyphenyl)-methanone serves as a valuable compound in research settings, where it can be explored for its potential interactions with biological systems and its capacity to influence various biochemical processes. Its complex structure makes it an intriguing candidate for studies aimed at understanding its behavior and effects at the molecular level.
Used in Pharmaceutical Development:
In the pharmaceutical industry, (1-methyl-1H-indol-5-yl)-(3,4,5-trimethoxyphenyl)-methanone may be employed as a starting point for the development of new drugs or as a component in the synthesis of medicinal compounds. Its unique structural features could potentially contribute to the creation of novel therapeutic agents, particularly if its biological activity is found to be beneficial in treating specific conditions or diseases.

Upstream product

• 90923-75-4 1-methyl-1H-indole-5-carboxaldehyde 
• 280563-07-7 1-methyl-5-iodoindole 
• 837392-62-8 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole 
• 10075-50-0 5-bromo-1H-indole 
• 10075-52-2 5-bromo-1-methyl-H-indole 
• 133095-91-7 3,4,5-trimethoxyphenylmagnesium bromide 
• 671215-62-6 1-(benzenesulfonyl)-1H-indole-5-carbaldehyde 
• 1196-69-6 1H-indole-5-carboxaldehyde 
• 946077-16-3 (1H-indol-5-yl)(3,4,5-trimethoxyphenyl)methanone 
• 74-88-4 methyl iodide 

Downstream Products

• 1192108-55-6 1-methyl-5-[1-(3,4,5-trimethoxyphenyl)vinyl]-1H-indole 
• 1427690-75-2 C₂₁H₂₁NO₄ 
• 1427690-77-4 C₂₂H₂₁NO₅ 
• 1427690-81-0 C₂₁H₂₁NO₅ 
• 1427690-82-1 1-methyl-5-(1-(3,4,5-trimethoxyphenyl)vinyl)-3-vinyl-1H-indole 
• 1427690-83-2 C₂₁H₂₅NO₃ 
• 1427690-88-7 C₂₁H₂₀N₂O₃ 
• 1427690-89-8 1-methyl-5-[1-(3,4,5-trimethoxyphenyl)vinyl]-1H-indole-3-carbaldehydeoxime acetate 
• 1427690-93-4 C₂₁H₂₂N₂O₄ 
• 1427690-94-5 C₂₁H₂₃NO₄ 
• 1427690-73-0 1-methyl-5-(3,4,5-trimethoxybenzoyl)-1H-indole-3-carbaldehyde 

Relevant articles and documents

Kinetically Controlled, Highly Chemoselective Acylation of Functionalized Grignard Reagents with Amides by N?C Cleavage

The direct transition-metal-free acylation of amides with functionalized Grignard reagents by highly chemoselective N?C cleavage under kinetic control has been accomplished. The method offers rapid and convergent access to functionalized biaryl ketones through transient tetrahedral intermediates. The direct access to functionalized Grignard reagents by in situ halogen–magnesium exchange promoted by the versatile turbo-Grignard reagent (iPrMgCl?LiCl) permits excellent substrate scope with respect to both the amide and Grignard coupling partners. These reactions enable facile, operationally simple and chemoselective access to tetrahedral intermediates from amides under significantly milder conditions than chelation-controlled intermediates. This novel direct two-component coupling sets the stage for using amides as acylating reagents in an alternative paradigm to the metal-chelated approach, acyl metals and Weinreb amides.

Synthesis, biological evaluation, and molecular docking analysis of phenstatin based indole linked chalcones as anticancer agents and tubulin polymerization inhibitors

A library of new phenstatin based indole linked chalcone compounds (9a-z and 9aa-ad) were designed and synthesized. Of these, compound 9a with 1-methyl, 2- and 3-methoxy substituents in the aromatic ring was efficacious against the human oral cancer cell

Nickel-catalysed Suzuki-Miyaura coupling of amides

The Suzuki-Miyaura coupling has become one of the most important and prevalent methods for the construction of C-C bonds. Although palladium catalysis has historically dominated the field, the use of nickel catalysis has become increasingly widespread because of its unique ability to cleave carbon-heteroatom bonds that are unreactive towards other transition metals. We report the first nickel-catalysed Suzuki-Miyaura coupling of amides, which proceeds by an uncommon cleavage of the amide C-N bond after N-tert-butoxycarbonyl activation. The methodology is mild, functional-group tolerant and can be strategically employed in sequential transition-metal-catalysed cross-coupling sequences to unite heterocyclic fragments. These studies demonstrate that amides, despite classically considered inert substrates, can be harnessed as synthons for use in reactions that form C-C bonds through cleavage of the C-N bond using non-precious metal catalysis.