1201897-76-8Relevant articles and documents
Asymmetric synthesis of aza-diospongin A as an iNOS inducer
Chandrasekhar,Kiran Babu,Raji Reddy
experimental part, p. 2216 - 2219 (2010/03/25)
The synthesis of the aza-analogue of diospongin A is described. The key steps in the synthetic sequence are Mitsunobu inversion, cross olefin metathesis and intramolecular aza-Michael addition reactions. The biological activity of this new analogue was also evaluated in the induction of nitric oxide synthase and was found to be better when compared to its natural counterpart.