1216-15-5 Usage
Description
(2E)-1-phenyl-2-(3-phenylprop-2-en-1-ylidene)hydrazine, also known as chalcone hydrazone, is an organic compound characterized by a hydrazone functional group. It is derived from chalcone, a naturally occurring compound found in a variety of plants. (2E)-1-phenyl-2-(3-phenylprop-2-en-1-ylidene)hydrazine has garnered interest due to its potential biological activities, which include anti-inflammatory, anti-cancer, and antibacterial properties. Moreover, it has been considered as a candidate ligand in coordination chemistry. Structurally, chalcone hydrazone features a phenyl group linked to a hydrazone moiety and is frequently utilized as a fundamental building block in organic synthesis. Its versatility in chemical reactions has also positioned it as a promising component in the creation of innovative materials, such as dyes and polymers.
Uses
Used in Pharmaceutical Industry:
(2E)-1-phenyl-2-(3-phenylprop-2-en-1-ylidene)hydrazine is used as a bioactive compound for its potential anti-inflammatory, anti-cancer, and antibacterial properties. Its diverse therapeutic applications are attributed to its ability to modulate various biological pathways and mechanisms, offering a broad spectrum of action against different diseases and conditions.
Used in Coordination Chemistry:
In the field of coordination chemistry, (2E)-1-phenyl-2-(3-phenylprop-2-en-1-ylidene)hydrazine is utilized as a potential ligand. Its interaction with metal ions can lead to the formation of coordination compounds with unique properties and potential applications in areas such as catalysis, sensing, and materials science.
Used in Organic Synthesis:
(2E)-1-phenyl-2-(3-phenylprop-2-en-1-ylidene)hydrazine is employed as a building block in organic synthesis. Its structural features and reactivity make it a valuable component in the construction of more complex organic molecules, contributing to the development of new pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Material Science:
(2E)-1-phenyl-2-(3-phenylprop-2-en-1-ylidene)hydrazine is used as a component in the development of new materials, such as dyes and polymers. Its capacity to participate in various chemical reactions allows for the creation of materials with tailored properties, suitable for applications in industries like textiles, coatings, and plastics.
Check Digit Verification of cas no
The CAS Registry Mumber 1216-15-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,2,1 and 6 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1216-15:
(6*1)+(5*2)+(4*1)+(3*6)+(2*1)+(1*5)=45
45 % 10 = 5
So 1216-15-5 is a valid CAS Registry Number.
1216-15-5Relevant articles and documents
Systematic study of the fluorescent properties of cinnamaldehyde phenylhydrazone and its interactions with metals: Synthesis and photophysical evaluation
Aguilar, Luis F.,Bravo, Manuel A.,Díaz, Katy,González, César,Mellado, Marco,Sariego-Kluge, Rafaela
, (2020)
Hydrazones are organic compounds with applications in various fields of research, including fluorescent applications. In this investigation, the compound cinnamaldehyde phenylhydrazone was synthesized by condensation between cinnamaldehyde (1) and phenylh
Facile One-Pot Transformation of Primary Alcohols into 3-Aryl- and 3-Alkyl-isoxazoles and -pyrazoles
Kobayashi, Eiji,Togo, Hideo
, p. 3723 - 3735 (2019/09/30)
Various primary alcohols were smoothly transformed into 3-aryl- and 3-alkylisoxazoles in good yields in one pot by successive treatment with PhI(OAc) 2 in the presence of TEMPO, NH 2 OH, and then NCS, followed by reaction with alkynes in the presence of Et 3 N. Similarly, various primary alcohols were smoothly transformed into 3-aryl- and 3-alkylpyrazoles in good yields in one pot by successive treatment with PhI(OAc) 2 in the presence of TEMPO, PhNHNH 2, and then NCS and decyl methyl sulfide, followed by reaction with alkynes in the presence of Et 3 N. Thus, both 3-aryl- and 3-alkylisoxazoles, and 3-aryl- and 3-alkylpyrazoles could be prepared from readily available primary alcohols in one pot under transition-metal-free conditions.
The use of enaminones and enamines as effective synthons for MSA-catalyzed regioselective synthesis of 1,3,4-tri- And 1,3,4,5-tetrasubstituted pyrazoles
Duan, Liancheng,Zhou, Hui,Gu, Yucheng,Gong, Ping,Qin, Mingze
supporting information, p. 16131 - 16137 (2019/11/03)
In the present work, an efficient regioselective synthesis of 1,3,4-tri- and 1,3,4,5-tetrasubstituted pyrazoles via a methanesulfonic acid (MSA)-catalyzed reaction of hydrazones with enaminones or enamines is reported. Mechanistically, the formation of the title compounds involves the [2+3] cycloaddition of hydrazones with enaminones or enamines followed by aromatization with acid and oxygen. This convenient method under mild conditions with various hydrazones, enaminones, and enamines was well-tolerated to afford products in good to excellent yields. Compared with the literature methods, this strategy has advantages such as materials that are available economically, metal-free catalysis, excellent regioselectivity, and high efficiency.
