1218811-70-1

Basic information

• Product Name: 2-(4-methoxyphenyl)-5-[(4-methylphenyl)ethynyl]-1,3,4-oxadiazole
• Synonyms: 2-(4-methoxyphenyl)-5-[(4-methylphenyl)ethynyl]-1,3,4-oxadiazole
• CAS NO: 1218811-70-1
• Molecular Weight: 290.321
• Mol File: 1218811-70-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(4-methoxyphenyl)-5-[(4-methylphenyl)ethynyl]-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)-5-[(4-methylphenyl)ethynyl]-1,3,4-oxadiazole(1218811-70-1)
• EPA Substance Registry System: 2-(4-methoxyphenyl)-5-[(4-methylphenyl)ethynyl]-1,3,4-oxadiazole(1218811-70-1)

Safety Data

• Hazardous Substances Data: 1218811-70-1(Hazardous Substances Data)

Upstream product

• 829-35-6 2-(4-methoxyphenyl)-1,3,4-oxadiazole 
• 766-97-2 4-n-methylphenylacetylene 
• 60512-56-3 1-(2,2-dibromovinyl)-4-methylbenzene 
• 104-87-0 4-methyl-benzaldehyde 
• 3290-99-1 4-methoxybenzoic acid hydrazide 
• 1368483-63-9 2-bromo-5-(4-methoxyphenyl)-1,3,4-oxadiazole 
• 2227-58-9 3-(4-methylphenyl)prop-2-ynoic acid 

Relevant articles and documents

Palladium-Catalyzed Decarboxylative Cross-Coupling of 1,3,4-Oxa-diazoles with Alkynoic Acids: A Simple Route for the Preparation of 2-Alkynylated 1,3,4-Oxadiazoles

For the first time 2-alk-1-ynyl-5-(het)aryl-1,3,4-oxadiazole derivatives have been synthesized by the decarboxylative cross-coupling of alk-2-ynoic acids with 2-(het)aryl-1,3,4-oxadiazoles, employing palladium(II) chloride as the catalyst and silver(I) oxide as an oxidant with 1,3-bis(diphenylphosphanyl)propane as a ligand. Products were formed in high yields with no byproduct.

Copper-mediated C-H activation of 1,3,4-oxadiazoles with 1,1-dibromo-1-alkenes using PEG-400 as a solvent medium: Distinct approach for the alkynylation of 1,3,4-oxadiazoles

The direct C-H alkynylation of 1,3,4-oxadiazoles with 1,1-dibromo-1-alkenes has been accomplished by using a combination of CuBr/LiOtBu in PEG-400 (a green solvent) at 80 °C. The products were formed in high yields (73-86%) in 2 h. No additional ligand or volatile solvent was required and the conversion was ecofriendly. The direct C-H alkynylation of 1,3,4-oxadiazoles with 1,1-dibromo-1-alkenes has been accomplished by using a combination of CuBr/LiOtBu in PEG-400 (a green solvent) at 80 °C. The products were formed in high yields (73-86%) in 2 h. No additional ligand or volatile solvent was required and the conversion was ecofriendly. Copyright