829-35-6

Basic information

• Product Name: 2-(4-methoxyphenyl)-1,3,4-oxadiazole
• Synonyms: 2-(4-methoxyphenyl)-1,3,4-oxadiazole
• CAS NO: 829-35-6
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.17202
• Mol File: 829-35-6.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 296.4°C at 760 mmHg
• Flash Point: 133.1°C
• Appearance: /
• Density: 1.190
• Vapor Pressure: 0.00254mmHg at 25°C
• Refractive Index: 1.534
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-(4-methoxyphenyl)-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)-1,3,4-oxadiazole(829-35-6)
• EPA Substance Registry System: 2-(4-methoxyphenyl)-1,3,4-oxadiazole(829-35-6)

Safety Data

• Hazardous Substances Data: 829-35-6(Hazardous Substances Data)

Usage

General Description

2-(4-methoxyphenyl)-1,3,4-oxadiazole is a chemical compound with the molecular formula C9H7N3O2. It is a heterocyclic compound that contains a five-membered oxadiazole ring. 2-(4-methoxyphenyl)-1,3,4-oxadiazole is commonly used in organic synthesis and has been studied for its potential pharmaceutical and agricultural applications. It has demonstrated antimicrobial, anti-inflammatory, and antiviral properties in some studies, and it is also being investigated for its potential use as a fluorescent probe in biological imaging. Additionally, 2-(4-methoxyphenyl)-1,3,4-oxadiazole has been used as a building block for the synthesis of various derivatives with diverse biological and chemical properties.

InChI:InChI=1/C9H8N2O2/c1-12-8-4-2-7(3-5-8)9-11-10-6-13-9/h2-6H,1H3

Upstream product

• 3290-99-1 4-methoxybenzoic acid hydrazide 
• 122-51-0 orthoformic acid triethyl ester 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 68-12-2 N,N-dimethyl-formamide 
• 1895-39-2 sodium chlorodifluoroacetate 
• 696-62-8 para-iodoanisole 
• 536-74-3 phenylacetylene 
• 100-42-5 styrene 
• 100-09-4 4-methoxybenzoic acid 
• 94-30-4 ethyl 4-methoxybenzoate 
• 121-98-2 methyl 4-methoxybenzoate 
• 149-73-5 trimethyl orthoformate 
• 74-83-9 methyl bromide 

Downstream Products

• 1026396-33-7 (1-{hydroxy-[5-(4-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-methyl}-2-methyl-propyl)-carbamic acid tert-butyl ester 
• 1181219-09-9 (E)-2-(1,2-diphenylvinyl)-5-(4-methoxyphenyl)-1,3,4-oxadiazole 
• 944672-79-1 2-benzyl-5-(4-methoxyphenyl)-1,3,4-oxadiazole 
• 1218811-70-1 2-(4-methoxyphenyl)-5-[(4-methylphenyl)ethynyl]-1,3,4-oxadiazole 
• 842-79-5 2-(4-methoxy-phenyl)-5-phenyl-[1,3,4]oxadiazole 
• 23767-54-6 4-[5-(4-methoxy-phenyl)-1,3,4-oxadiazol-2-yl]morpholine 
• 1261274-33-2 rac-N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-S-methyl-S-phenylsulfoximine 
• 1309444-88-9 2-(4-methoxyphenyl)-5-(2-phenylbenzofuran-3-yl)-1,3,4-oxadiazole 
• 1323158-95-7 4-methoxy-N'-(piperidin-1-ylmethylidene)benzohydrazide 
• 23767-53-5 4-[5-(4-methoxy-phenyl)-1,3,4-oxadiazol-2-yl]piperidine 
• 1352834-49-1 2-(N-benzyl-N-methylamino)-5-(4-methoxyphenyl)-1,3,4-oxadiazole 
• 55439-48-0 2-(benzo[d]thiazol-2-yl)-5-(4-methoxyphenyl)-1,3,4-oxadiazole 
• 1446317-68-5 2-(4-methoxyphenyl)-5-(pentafluorophenyl)-1,3,4-oxadiazole 
• 1446317-78-7 2-(4-methoxyphenyl)-5-(1-trifluoromethyl-2,3,5,6-tetrafluorophenyl)-1,3,4-oxadiazole 

Relevant articles and documents

Copper-Catalyzed Enantioconvergent Cross-Coupling of Racemic Alkyl Bromides with Azole C(sp2)?H Bonds

The development of enantioconvergent cross-coupling of racemic alkyl halides directly with heteroarene C(sp2)?H bonds has been impeded by the use of a base at elevated temperature that leads to racemization. We herein report a copper(I)/cinchona-alkaloid-derived N,N,P-ligand catalytic system that enables oxidative addition with racemic alkyl bromides under mild conditions. Thus, coupling with azole C(sp2)?H bonds has been achieved in high enantioselectivity, affording a number of potentially useful α-chiral alkylated azoles, such as 1,3,4-oxadiazoles, oxazoles, and benzo[d]oxazoles as well as 1,3,4-triazoles, for drug discovery. Mechanistic experiments indicated facile deprotonation of an azole C(sp2)?H bond and the involvement of alkyl radical species under the reaction conditions.

Ligand-Enabled Palladium-Catalyzed Through-Space C?H Bond Activation via a Carbopalladation/1,4-Pd Migration/C?H Functionalization Sequence

We report, herein, a palladium-catalyzed cascade comprising carbopalladation, 1,4-Pd-migration and C(sp2)?C(sp2) bond formation to construct a variety of bis-heterocyclic frameworks in a single operational step. The methodology provi

Method for one-step construction of 2-(4-methoxyphenyl)-1,3,4-oxadiazole by using DMF as carbon source

The invention discloses a method for one-step construction of 2-(4-methoxyphenyl)-1,3,4-oxadiazole by using DMF (N,N-dimethylformamide) as a carbon source. According to the present invention, 2-(4-methoxyphenyl)-1,3,4-oxadiazole is subjected to one-step c