1246616-95-4

Basic information

• Product Name: ethyl (S)-5-(benzyloxy)-1-(1-hydroxy-3-phenylpropan-2-yl)-6-((2-methoxyethyl) carbamoyl)-4-oxo-1,4-dihydropyridine-3-carboxylate
• Synonyms: ethyl (S)-5-(benzyloxy)-1-(1-hydroxy-3-phenylpropan-2-yl)-6-((2-methoxyethyl) carbamoyl)-4-oxo-1,4-dihydropyridine-3-carboxylate
• CAS NO: 1246616-95-4
• Molecular Weight: 508.571
• Mol File: 1246616-95-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl (S)-5-(benzyloxy)-1-(1-hydroxy-3-phenylpropan-2-yl)-6-((2-methoxyethyl) carbamoyl)-4-oxo-1,4-dihydropyridine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (S)-5-(benzyloxy)-1-(1-hydroxy-3-phenylpropan-2-yl)-6-((2-methoxyethyl) carbamoyl)-4-oxo-1,4-dihydropyridine-3-carboxylate(1246616-95-4)
• EPA Substance Registry System: ethyl (S)-5-(benzyloxy)-1-(1-hydroxy-3-phenylpropan-2-yl)-6-((2-methoxyethyl) carbamoyl)-4-oxo-1,4-dihydropyridine-3-carboxylate(1246616-95-4)

Safety Data

• Hazardous Substances Data: 1246616-95-4(Hazardous Substances Data)

Upstream product

• 3182-95-4 L-Phenylalaninol 
• 1246616-94-3 ethyl 5-(benzyloxy)-6-((2-methoxyethyl)carbamoyl)-4-oxo-4H-pyran-3-carboxylate 
• 1246616-93-2 3-(benzyloxy)-5-(ethoxycarbonyl)-4-oxo-4H-pyran-2-carboxylic acid 
• 1246616-92-1 ethyl 5-(benzyloxy)-6-formyl-4-oxo-4H-pyran-3-carboxylate 
• 67354-34-1 ethyl 4-benzyloxyacetoacetate 
• 727382-68-5 4-benzyloxy-2-(1-dimethylaminomethylidene)-3-oxo-butyric acid ethyl ester 
• 19810-31-2 Benzyloxyacetyl chloride 
• 100-51-6 benzyl alcohol 
• 638-07-3 ethyl (2-chloroaceto)acetate 
• 924-99-2 ethyl 3-(dimethylamino)acrylate 

Downstream Products

• 1246616-97-6 (S)-4-benzyl-9-(benzyloxy)-2-(2-methoxyethyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-7-carboxylic acid 
• 1246616-98-7 (S)-4-benzyl-9-hydroxy-2-(2-methoxyethyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-7-carboxylic acid 
• 1246616-96-5 ethyl (S)-4-benzyl-9-(benzyloxy)-2-(2-methoxyethyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-7-carboxylate 

Relevant articles and documents

Synthesis and SAR Study of Carbamoyl Pyridone Bicycle Derivatives as Potent Inhibitors of Influenza Cap-dependent Endonuclease

The medicinal chemistry and structure-activity relationships (SAR) for a novel series of carbamoyl pyridone bicycle (CAB) compounds as influenza Cap-dependent endonuclease (CEN) inhibitors are disclosed. Substituent effects were evaluated at the C (N)-1, N-3, and C-7 positions of the CAB ring system using a docking study. Submicromolar EC50 values were achieved in the cellular assay with C-7-unsubstituted CAB which possessed a benzhydryl group on either the C-1 or the N-1 position. An N-3 substituent was found to be critical for the plasma protein binding effect in vitro, and the CAB-N analogue 2v exhibited reasonable total clearance (CLtot). More importantly, compound 2v displayed significant efficacy in a mouse model infected with influenza viruses.