128954-45-0

Basic information

• Product Name: formoterol
• Synonyms: Formamide, N-[2-hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-;ForMoterol (Mixture of DiastereoMers)
• CAS NO: 128954-45-0
• Molecular Formula: C₁₉H₂₄N₂O₄
• Molecular Weight: 344.4
• Mol File: 128954-45-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: formoterol(CAS DataBase Reference)
• NIST Chemistry Reference: formoterol(128954-45-0)
• EPA Substance Registry System: formoterol(128954-45-0)

Safety Data

• Hazardous Substances Data: 128954-45-0(Hazardous Substances Data)

Usage

Description

Formoterol, a selective β2-adrenergic receptor agonist, is a medication primarily used for the treatment of respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD). It works by relaxing the muscles in the airways, leading to improved lung function and easier breathing.

Uses

Used in Pharmaceutical Industry:
Formoterol is used as an antiasthmatic agent for the treatment of asthma and chronic obstructive pulmonary disease (COPD). It helps to relax the muscles in the airways, providing relief from symptoms such as shortness of breath, wheezing, and coughing.
Additionally, formoterol can be used in combination with other medications, such as corticosteroids, to manage severe asthma cases and reduce the frequency of asthma attacks. Its selective action on β2-adrenergic receptors ensures targeted relief with minimal side effects compared to non-selective bronchodilators.

Upstream product

• 43229-65-8 [2-(4-methoxyphenyl)-1-methylethyl](phenylmethyl)amine 
• 51582-41-3 2-(3-benzyloxy-4-nitrophenyl)oxirane 
• 43229-67-0 1-(4-benzyloxy-3-nitrobenzene)-2-{benzyl-[2-(4-methoxyphenyl)-1-methylethyl]amino}ethanol 
• 43229-68-1 1-(4-benzyloxy-3-aminobenzene)-2-{benzyl-[2-(4-methoxyphenyl)-1-methylethyl]amino}ethanol 
• 43229-69-2 N-[5-(2-{Benzyl-[2-(4-methoxy-phenyl)-1-methyl-ethyl]-amino}-1-hydroxy-ethyl)-2-benzyloxy-phenyl]-formamide; compound with (E)-but-2-enedioic acid 
• 43229-70-5 N-[5-(2-{benzyl[2-(4-methoxyphenyl)-1-methylethyl]amino}-1-hydroxyethyl)-2-benzyloxyphenyl]formamide 

Downstream Products

• 615551-59-2 2-(formylamino)-4-(1-hydroxy-2-{[2-(4-methoxyphenyl)-1-methylethyl]amino}ethyl)phenyl β-D-glucopyranosiduronic acid 
• 169375-55-7 formoterol fumarate 
• 183814-30-4 formoterol fumarate dihydrate 

Relevant articles and documents

Preparation method and application of formoterol and medicinal salt thereof

The invention provides a preparation method and application of formoterol and medicinal salt thereof, and relates to the technical field of chemical synthesis. The preparation method of formoterol comprises the following steps: reacting a compound shown as a formula I under the action of a palladium-containing catalyst, a hydrogen donor and an alkali reagent to obtain a compound shown as a formulaII, wherein the hydrogen donor is a combination of formic acid and ammonium formate. The compound shown in the formula I contains O-benzyl, N-benzyl, formyl and methoxyl at the same time, hydrogen can be slowly and continuously generated under the action of a palladium-containing catalyst by adopting the combination of a hydrogen donor and an alkali reagent, a method for directly introducing hydrogen in the conventional technology is replaced, benzyl of O-benzyl and N-benzyl on the compound shown in the formula I can be removed, formyl and methoxyl are not affected, the yield and purity of the product are guaranteed, reaction conditions are mild, technological operation is safe and easy to control, and the method is simple, convenient and easy to implement and suitable for large-scale production.

Raising of pigs

The fat content of sows' milk is increased, thereby increasing the energy supplied to the sow's piglets, by administering one of a small group of phenethanolamines.