129397-81-5

Basic information

• Product Name: L-Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, methyl ester
• CAS NO: 129397-81-5
• Molecular Formula: C25H23NO4
• Molecular Weight: 401.462
• Mol File: 129397-81-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: L-Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, methyl ester(129397-81-5)
• EPA Substance Registry System: L-Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, methyl ester(129397-81-5)

Safety Data

• Hazardous Substances Data: 129397-81-5(Hazardous Substances Data)

Upstream product

• 63-91-2 L-phenylalanine 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 126727-04-6 2-(9-fluorenylmethoxycarbonylamino)-3-phenylpropionic acid 
• 67-56-1 methanol 
• 35661-40-6 N-Fmoc L-Phe 
• 150-30-1 Phenylalanine 
• 85622-93-1 temozolomide 
• 394210-45-8 4-benzyl-2,5-dioxo-oxazolidine-3-carboxylic acid 9H-fluoren-9-ylmethyl ester 
• 35909-92-3 N-carbobenzoxy-L-phenylalanine methyl ester 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 

Downstream Products

• 3618-96-0 (S)-N-acetylphenylalanine 
• 51220-86-1 N-(p-toluenesulfonyl)-L-phenylalanine methyl ester 
• 84000-03-3 9H-fluoren-9-ylmethyl (S)-4-benzyl-5-oxo-1,3-oxazolidine-3-carboxylate 
• 43041-59-4 methyl (S)-(-)-2-isocyano-3-phenylpropionate 
• 1258863-43-2 (S)-methyl 2-isoselenocyanato-3-phenylpropanoate 
• 63-91-2 L-phenylalanine 
• 16227-22-8 glycyl-L-phenylalanine methyl ester 
• 71921-20-5 methyl glycylglycyl-L-phenylalaninate 
• 1393661-65-8 C₅₇H₅₉N₇O₁₀ 
• 1393661-64-7 C₅₆H₅₇N₇O₁₀ 
• 1393661-63-6 C₃₇H₃₈N₆O₇ 
• 159789-40-9 C₃₈H₃₈N₄O₈ 
• 1393661-62-5 C₂₉H₂₉N₃O₆ 
• 35661-40-6 N-Fmoc L-Phe 

Relevant articles and documents

Model Studies on Protease-Catalysed Peptide Synthesis Using 9-Fluorenylmethoxycarbonyl Protected Amino Acid Derivatives

Fmoc-Phe-OMe, Fmoc-Ala-OMe and Fmoc-Gly-OH were coupled with H-Leu-NH2 under catalytic action of chymotrypsin, papain and thermolysin, respectively.The influence of different reaction media and several reaction parameters, such as reactants and enzyme con

Imidazotetrazines as Weighable Diazomethane Surrogates for Esterifications and Cyclopropanations

Diazomethane is one of the most versatile reagents in organic synthesis, but its utility is limited by its hazardous nature. Although alternative methods exist to perform the unique chemistry of diazomethane, these suffer from diminished reactivity and/or correspondingly harsher conditions. Herein, we describe the repurposing of imidazotetrazines (such as temozolomide, TMZ, the standard of care for glioblastoma) for use as synthetic precursors of alkyl diazonium reagents. TMZ was employed to conduct esterifications and metal-catalyzed cyclopropanations, and results show that methyl ester formation from a wide variety of substrates is especially efficient and operationally simple. TMZ is a commercially available solid that is non-explosive and non-toxic, and should find broad utility as a replacement for diazomethane.

Aqueous MW eco-friendly protocol for amino group protection

In this paper a new catalyst-free and on-water method for protection of amines and amino acids with di-tert-butyl dicarbonate, 9-fluorenylmethoxycarbonyl chloride, acetyl chloride and tosyl chloride is presented. The protection can be realized in a few minutes under microwave-assistance. The reaction proved to be chemoselective in presence of ambident nucleophiles and water solution of di-tert-butyl carboxylic acid or chloride acid are the only wastes produced.