130336-16-2Relevant articles and documents
Preparation method of 3, 5-substituted-4-amino trifluoroacetophenone and derivatives thereof
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, (2021/11/19)
The invention relates to the field of organic pharmaceutical synthesis, in particular to a preparation method of 3, 5-substituted-4-amino trifluoroacetophenone and derivatives thereof, and the preparation method of the 3, 5-substituted-4-amino trifluoroacetophenone comprises the following steps: by taking ortho-disubstituted p-aniline as a raw material, carrying out amino protection, acylation reaction and amino deprotection to obtain 4-amino trifluoroacetophenone. The reaction raw materials are simple and easy to obtain, the yield is relatively high, the reaction conditions are mild, and the method has a relatively good industrial application prospect. Besides, on the basis of the reaction, the 3, 5-substituted-4-amino trifluoroacetophenone is further subjected to amino diazotization to prepare the derivative of the 3, 5-substituted-4-amino trifluoroacetophenone, and the derivative has a relatively great application prospect in industry.
PROCESS FOR THE PREPARATION OF 3,5-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE
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Page/Page column 8-9, (2021/12/08)
The present invention relates to an improved process for the preparation of 3,5-Dichloro-2,2,2-Trifluoroacetophenone of formula (I). The present invention further provides an improved process for the preparation of Fluralaner using 3,5-dichloro-2,2,2-trifluoroacetophenone of formula (I) obtained by a process described herein.
Synthesis method of 3', 5'-dichloro-2, 2, 2-trifluoroacetophenone
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Paragraph 0025-0028; 0077, (2020/12/15)
The invention relates to the technical field of chemical pharmacy, in particular to a synthesis method of 3', 5' dichloro-2, 2, 2-trifluoroacetophenone. The method comprises the following steps of: reacting 1, 3, 5-trichlorobenzene or 3, 5-dichloro-1-bromobenzene with magnesium to form a Grignard reagent, carrying out nucleophilic addition reaction on the Grignard reagent and a trifluoroacetyl reagent; and carrying out acid treatment to obtain 3', 5'-dichloro-2, 2, 2-trifluoroacetophenone; the method has the advantages of mild reaction conditions, low raw material cost, favorable economic effect and wide industrial production prospects.