134168-97-1Relevant articles and documents
NOVEL COMPOUND FOR ORGANIC ELECTROLUMINESCENT DEVICE AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME
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Paragraph 0119-0121; 0182-0184, (2016/10/10)
Provided are a compound for an organic light emitting device and an organic light emitting device comprising the same. To this end, it is possible to provide a compound for an organic light emitting device which can be used as a host, a hole-transport material, or an electron-transport material capable of enhancing light-emitting efficiency of phosphorescent light-emitting materials by having outstanding electrical stability, an electron and hole transportability, and a high level of triplet state energy, and the organic light emitting device.
3-[Substituted]-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitriles: Identification of highly potent and selective metabotropic glutamate subtype 5 receptor antagonists
Tehrani, Lida R.,Smith, Nicholas D.,Huang, Dehua,Poon, Steve F.,Roppe, Jeffrey R.,Seiders, Thomas Jon,Chapman, Deborah F.,Chung, Janice,Cramer, Merryl,Cosford, Nicholas D.P.
, p. 5061 - 5064 (2007/10/03)
Structure-activity relationship studies on the phenyl ring of 3-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitrile 2 led to the discovery that small, non-hydrogen bond donor substituents at the 3-position led to a substantial increase in in vitro potency. In particular, 3-fluoro-5-(5-pyridin- 2-yl-2H-tetrazol-2-yl)benzonitrile (7) is a highly potent and selective mGlu5 receptor antagonist with good rat pharmacokinetics, brain penetration, and in vivo receptor occupancy.
Biologically selective potassium channel openers having 1,1- diethylpropyl group
Yoshiizumi, Kazuya,Seko, Norihiko,Nishimura, Noriyasu,Ikeda, Shoji,Yoshino, Kohichiro,Kondo, Hirosato,Tanizawa, Kazutaka
, p. 3397 - 3402 (2007/10/03)
To find out selective potassium channel openers (PCOs), we synthesized several 3,5-disubstituted phenylcyanoguanidine derivatives and investigated their structure-activity relationships (SAR). As a result, we discovered selective PCOs having 1,1-diethylpropyl group toward antihypertensive activity.