1351373-50-6 Usage
Description
Bis-Propargyl-PEG13 is a PEG-based (polyethylene glycol-based) linker specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs). It possesses unique properties that allow it to effectively connect and stabilize target proteins and E3 ubiquitin ligases, facilitating the degradation of the target protein.
Uses
Used in Pharmaceutical Industry:
Bis-Propargyl-PEG13 is used as a linker in the development of PROTACs for the purpose of inducing the targeted degradation of specific proteins. This innovative approach has the potential to revolutionize the treatment of various diseases, including cancer and other proteinopathies, by selectively removing disease-causing or toxic proteins from the cell.
Used in Drug Discovery and Development:
Bis-Propargyl-PEG13 is utilized as a key component in the design and synthesis of novel therapeutic agents. Its ability to enhance the stability and efficacy of PROTACs makes it a valuable tool in the drug discovery process, allowing researchers to explore new avenues for treating a wide range of diseases.
Used in Chemical Synthesis:
In the field of chemical synthesis, Bis-Propargyl-PEG13 serves as a versatile building block for creating complex molecular structures. Its unique properties enable the formation of stable and functionalized compounds, which can be further modified or optimized for specific applications in various industries, including pharmaceuticals, materials science, and biotechnology.
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
structure and hydrogen bonding
Bis-propargyl-PEG13 comprises two propargyl groups which can form triazole linkages with azide-bearing compounds or biomolecules in copper catalyzed Click Chemistry reactions. The hydrophilic PEG units help improve the solubility of the molecule in aqueous media.
Check Digit Verification of cas no
The CAS Registry Mumber 1351373-50-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,1,3,7 and 3 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1351373-50:
(9*1)+(8*3)+(7*5)+(6*1)+(5*3)+(4*7)+(3*3)+(2*5)+(1*0)=136
136 % 10 = 6
So 1351373-50-6 is a valid CAS Registry Number.
1351373-50-6Relevant articles and documents
Convergent synthesis and characterization of dumbbell type dendritic materials by click chemistry
Sung, Sae Reum,Han, Seung Choul,Jin, Sung-Ho,Lee, Jae Wook
experimental part, p. 3933 - 3940 (2012/03/26)
General, fast, and efficient stitching methods for the synthesis of dendrimers with linear PEG units at a core, as dendritic-linear-dendritic materials, were developed. The synthetic strategy involved the click reaction between an alkyne and an azide. The
