1373151-95-1

Basic information

• Product Name: tert-butyl 4-({4-[5-(4,4,4-trifluorobutyl)pyridin-2-yl]phenyl}sulfonyl)tetrahydro-2H-pyran-4-carboxylate
• Synonyms: tert-butyl 4-({4-[5-(4,4,4-trifluorobutyl)pyridin-2-yl]phenyl}sulfonyl)tetrahydro-2H-pyran-4-carboxylate
• CAS NO: 1373151-95-1
• Molecular Weight: 513.578
• Mol File: 1373151-95-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-({4-[5-(4,4,4-trifluorobutyl)pyridin-2-yl]phenyl}sulfonyl)tetrahydro-2H-pyran-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-({4-[5-(4,4,4-trifluorobutyl)pyridin-2-yl]phenyl}sulfonyl)tetrahydro-2H-pyran-4-carboxylate(1373151-95-1)
• EPA Substance Registry System: tert-butyl 4-({4-[5-(4,4,4-trifluorobutyl)pyridin-2-yl]phenyl}sulfonyl)tetrahydro-2H-pyran-4-carboxylate(1373151-95-1)

Safety Data

• Hazardous Substances Data: 1373151-95-1(Hazardous Substances Data)

Upstream product

• 639492-78-7 terrt-butyl 4-{[4-(5-bromo-2-pyridyl)phenyl]sulfonyl}perhydro-2H-pyran-4-carboxylate 
• 461-17-6 1,1,1-trifluoro-4-iodo-butane 

Relevant articles and documents

ARYLSULFONYLHYDROXAMIC ACID AND AMIDE DERIVATIVES AND THEIR USE AS PROTEASE INHIBITORS

This invention is directed generally to hydroxamic acid and amide compounds (including salts of such compounds), and, more particularly, to aryl- and heteroaryl--arylsulfonylmethyl hydroxamic acids and amides that, inter alia, inhibit protease activity, particularly matrix metalloproteinase (also known as "matrix metalloprotease" or "MMP") activity and/or aggrecanase activity. These compounds generally correspond in structure to formula (I): wherein Al, A2, A3, El, E2, E3, and E4 are as defined in this patent. This invention also is directed to compositions of such compounds, intermediates for the syntheses of such compounds, methods for making such compounds, and methods for treating conditions associated with MMP activity and/or aggrecanase activity, particularly pathological conditions.