139717-71-8

Basic information

• Product Name: 1H-Indole, 5-methoxy-1-[(4-methylphenyl)sulfonyl]-
• CAS NO: 139717-71-8
• Molecular Formula: C16H15NO3S
• Molecular Weight: 301.366
• Mol File: 139717-71-8.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 5-methoxy-1-[(4-methylphenyl)sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 5-methoxy-1-[(4-methylphenyl)sulfonyl]-(139717-71-8)
• EPA Substance Registry System: 1H-Indole, 5-methoxy-1-[(4-methylphenyl)sulfonyl]-(139717-71-8)

Safety Data

• Hazardous Substances Data: 139717-71-8(Hazardous Substances Data)

Usage

Chemical classification

1H-Indole, 5-methoxy-1-[(4-methylphenyl)sulfonyl]is a derivative of indole, an aromatic heterocyclic organic compound.

Molecular structure

The compound consists of an indole ring with a methoxy group at the 5th position and a sulfonyl group attached to the 1st position via a phenyl group.

Sulfonyl group substitution

The sulfonyl group in the compound is further substituted with a methyl group.

Usage in organic synthesis

1H-Indole, 5-methoxy-1-[(4-methylphenyl)sulfonyl]is commonly used as a starting material for the synthesis of various pharmaceuticals and biologically active compounds.

Importance as an intermediate

The unique structure and reactivity of the compound make it an important intermediate in the production of drugs, agrochemicals, and other fine chemicals.

Upstream product

• 39755-95-8 5-methoxyisatine 
• 98-59-9 p-toluenesulfonyl chloride 
• 1192805-58-5 N-(4-methoxy-2-vinylphenyl)-4-methylbenzenesulfonamide 
• 210536-47-3 2-ethenyl-4-methoxybenzenamine 
• 32338-02-6 2-bromo-4-methoxyaniline 
• 139717-79-6 2-(1-isopropylthio-2-methoxyethyl)-4-methoxyaniline 
• 104-94-9 4-methoxy-aniline 
• 402822-76-8 N-allyl-N-p-toluenesulfonyl-2-ethenyl-4-methoxyaniline 
• 1150-26-1 N-(4-Methoxy-phenyl)-4-methyl-benzenesulfonamide 
• 1822-73-7 phenylthioethylene 
• 1006-94-6 5-methoxylindole 
• 139717-69-4 N-tosyl-2-(1-isopropylthio-2-methoxyethyl)-4-methoxyanilide 

Downstream Products

• 1027787-52-5 C₂₃H₂₁NO₄S 

Relevant articles and documents

A Catalytic Construction of Indoles via Formation of Ruthenium Vinylidene Species from N-Arylynamides

Treatment of ynamides with a catalytic amount of TpRuCl(PPh3)2 resulted in the construction of indole scaffolds known as privileged structure motifs. This reaction involved a cascade of 1,2-rearrangement and cyclization carrying out C?C bond formation via a ruthenium vinylidene intermediate, as revealed by a deuterium-labeling experiments. Furthermore, the transformation of multi-functionalized ynamide, derived from a practical drug molecule, showed a high functional group tolerance of this reaction. (Figure presented.).

A Series of 2-((1-Phenyl-1H-imidazol-5-yl)methyl)-1H-indoles as Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors

Indoleamine 2,3-dioxygenase 1 (IDO1) is a promising therapeutic target in cancer immunotherapy and neurological disease. Thus, searching for highly active inhibitors for use in human cancers is now a focus of widespread research and development efforts. I

Silver-Catalyzed Asymmetric Dearomatization of Electron-Deficient Heteroarenes via Interrupted Barton–Zard Reaction

Herein we report a catalytic asymmetric dearomatization reaction of electron-deficient heteroarenes with α-substituted isocyanoacetates through an interrupted Barton–Zard reaction. A range of optically active pyrrolo[3,4-b]indole derivatives was obtained