1400691-55-5 Usage
Description
C9H16N2C3H2F6O2, also known as Colby Trifluoromethylation Reagent, is an amidinate salt of hexafluoroacetone hydrate. It is an air-stable, white solid that can be used as a source of fluoroform through the release of trifluoroacetate. This reagent is known for its ability to add trifluoromethyl groups in a nucleophilic fashion to carbonyls and sulfides, making it a versatile compound in various chemical reactions.
Uses
1. Used in Pharmaceutical Industry:
C9H16N2C3H2F6O2 is used as a reagent for the synthesis of various pharmaceutical compounds. The trifluoromethylation reactions facilitated by this reagent allow for the introduction of trifluoromethyl groups into drug molecules, which can enhance their pharmacological properties, such as increasing lipophilicity, metabolic stability, and bioavailability.
2. Used in Chemical Synthesis:
In the field of chemical synthesis, C9H16N2C3H2F6O2 is used as a key reagent for the introduction of trifluoromethyl groups into organic molecules. This can be particularly useful in the synthesis of complex organic compounds, such as natural products and bioactive molecules, where the presence of a trifluoromethyl group can significantly alter the molecule's properties and reactivity.
3. Used in Material Science:
C9H16N2C3H2F6O2 can be employed in the development of novel materials with enhanced properties. The trifluoromethylation reactions enabled by this reagent can be used to modify the surface properties of materials, such as polymers and nanoparticles, leading to improved performance in various applications, including coatings, sensors, and energy storage devices.
4. Used in Research and Development:
As a versatile reagent for trifluoromethylation reactions, C9H16N2C3H2F6O2 is widely used in research and development laboratories. It allows chemists to explore new reaction pathways and develop innovative synthetic methods, contributing to the advancement of chemical science and technology.
Check Digit Verification of cas no
The CAS Registry Mumber 1400691-55-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,0,0,6,9 and 1 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1400691-55:
(9*1)+(8*4)+(7*0)+(6*0)+(5*6)+(4*9)+(3*1)+(2*5)+(1*5)=125
125 % 10 = 5
So 1400691-55-5 is a valid CAS Registry Number.
1400691-55-5Relevant articles and documents
Amidinate salt of hexafluoroacetone hydrate for the preparation of fluorinated compounds by the release of trifluoroacetate
Riofski, Mark V.,Hart, Allison D.,Colby, David A.
supporting information, p. 208 - 211 (2013/04/10)
A powerful, new reagent, an amidinate salt of hexafluoroacetone hydrate, is an air-stable salt that can be used for the preparation of fluorinated organic molecules. Nucleophilic trifluoromethylation reactions are demonstrated following the base-promoted release of trifluoroacetate. This reagent is soluble in many polar organic solvents and produces fluoroform, following the release of trifluoroacetate. Reactions with this reagent and common electrophiles provide excellent yields of trifluoromethylated products.
