379-21-5

Basic information

• Product Name: 2,2,2-TRIFLUORO-1,1-BIS(4-METHOXYPHENYL)ETHANOL
• Synonyms: 2,2,2-TRIFLUORO-1,1-BIS(4-METHOXYPHENYL)ETHANOL;alpha-Trifluoromethyl-4,4'-bis(methoxy)benzhydrol
• CAS NO: 379-21-5
• Molecular Formula: C₁₆H₁₅F₃O₃
• Molecular Weight: 312.28
• Mol File: 379-21-5.mol
• Article Data: 12

Chemical Properties

• Melting Point: 76°C
• Boiling Point: 411°C at 760 mmHg
• Flash Point: 185.4°C
• Appearance: /
• Density: 1.258g/cm³
• Vapor Pressure: 1.72E-07mmHg at 25°C
• Refractive Index: 1.517
• CAS DataBase Reference: 2,2,2-TRIFLUORO-1,1-BIS(4-METHOXYPHENYL)ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-TRIFLUORO-1,1-BIS(4-METHOXYPHENYL)ETHANOL(379-21-5)
• EPA Substance Registry System: 2,2,2-TRIFLUORO-1,1-BIS(4-METHOXYPHENYL)ETHANOL(379-21-5)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 379-21-5(Hazardous Substances Data)

Usage

General Description

2,2,2-TRIFLUORO-1,1-BIS(4-METHOXYPHENYL)ETHANOL is a chemical compound that belongs to the class of fluorinated alcohols. It is a colorless liquid with a high boiling point and is used in various industrial applications as a solvent, intermediate, or reagent in organic synthesis. 2,2,2-TRIFLUORO-1,1-BIS(4-METHOXYPHENYL)ETHANOL is known for its strong electron-withdrawing trifluoromethyl and hydroxyl groups, which make it suitable for use in pharmaceutical and agrochemical industries. Additionally, the presence of phenyl rings also imparts stability and reactivity to the molecule, making it a versatile building block for the synthesis of complex organic molecules.

InChI:InChI=1/C16H15F3O3/c1-21-13-7-3-11(4-8-13)15(20,16(17,18)19)12-5-9-14(22-2)10-6-12/h3-10,20H,1-2H3

Upstream product

• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 407-25-0 trifluoroacetic anhydride 
• 696-62-8 para-iodoanisole 
• 844-40-6 diphenylmethanol trifluoroacetate 
• 75-46-7 trifluoromethan 
• 90-96-0 bis(p-methoxyphenyl)methanone 
• 421-53-4 2,2,2-trifluoro-1,1-ethanediol 
• 1400691-55-5 C₉H₁₆N₂*C₃H₂F₆O₂ 
• 383-63-1 ethyl trifluoroacetate, 
• 262370-15-0 1,1-bis(p-methoxyphenyl)-2,2,2-trifluoroethyl chloride 

Downstream Products

• 262370-15-0 1,1-bis(p-methoxyphenyl)-2,2,2-trifluoroethyl chloride 
• 384-97-4 4,4'-(2,2,2-trifluoroethane-1,1-diyl)bis(methoxybenzene) 

Relevant articles and documents

One-Pot and Reducible-Functional-Group-Tolerant Synthesis of α-Aryl- and α-Heteroaryl-α-Trifluoromethyl Alcohols via Tandem Trifluoroacetylation and MPV Type Reduction

We have developed a new one-pot synthesis of α-aryl- and α-heteroaryl-α-trifluoromethyl alcohols carrying not only arenes with electron-withdrawing groups but also electron-deficient nitrogen-containing heteroarenes, which are of increasing interest becau

METHOD FOR PRODUCING TRIFLUOROMETHYL GROUP-CONTAINING ALCOHOLS

PROBLEM TO BE SOLVED: To provide a method for producing CF3 group-containing alcohols useful as production intermediates for medicines and agrochemicals. SOLUTION: The method for producing CF3 group-containing alcohols represented by formula (2) comprises

Nucleophilic trifluoromethylation of carbonyl compounds: Trifluoroacetaldehyde hydrate as a trifluoromethyl source

A feasible nucleophilic trifluoromethylating protocol has been developed using trifluoroacetaldehyde hydrate as an atom-economical trifluoromethyl source. The reaction was found to be applicable to the nucleophilic trifluoromethylation of a broad spectrum of carbonyl compounds with satisfactory yields in general. DFT calculations have been performed to provide mechanistic insight into the present and related reactions employing 2,2,2-trifluoro-1- methoxyethanol and hexafluoroacetone hydrate.