14019-10-4 Usage
Description
Methadol, also known as (-)-α-Methadol, is a synthetic opioid analgesic with a chemical structure similar to methadone. It is used in the treatment of opioid addiction and has been found to have a higher affinity for opiate receptors compared to its enantiomer, (+)-α-Methadol. Methadol is a metabolite of (-)-α-Acetylmethadol (A186325), and its relative activities are reversed upon acetylation.
Uses
Used in Opioid Addiction Treatment:
Methadol is used as a therapeutic agent for the treatment of opioid addiction. It helps in reducing withdrawal symptoms and cravings associated with opioid dependence, facilitating a smoother recovery process for patients.
Used in Pain Management:
Methadol is used as an analgesic for the management of moderate to severe pain. Its high affinity for opiate receptors allows it to effectively alleviate pain and provide relief to patients suffering from various conditions.
Used in Research:
Methadol is used as a research tool in the study of opiate receptors and their role in pain perception, addiction, and other related conditions. Its unique properties make it valuable for understanding the mechanisms of opioid action and developing new treatments for pain and addiction.
Check Digit Verification of cas no
The CAS Registry Mumber 14019-10-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,0,1 and 9 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 14019-10:
(7*1)+(6*4)+(5*0)+(4*1)+(3*9)+(2*1)+(1*0)=64
64 % 10 = 4
So 14019-10-4 is a valid CAS Registry Number.
14019-10-4Relevant articles and documents
Synthesis of optically active methadones, LAAM and bufuralol by lipase-catalysed acylations
Hull, Jonathan D.,Scheinmann, Feodor,Turner, Nicholas J.
, p. 567 - 576 (2007/10/03)
(R)- and (S)-Methadones and levo-α-acetylmethadol (LAAM) have been synthesised starting from lipase-catalysed acylation of dimethylaminopropan-2-ol. An approach to the synthesis of (R)-bufuralol is also presented.
Synthesis of a new metabolite of acetylmethadol
Booher,Pohland
, p. 266 - 268 (2007/10/06)
The primary amine metabolites of α (±) and α (-) acetylmethadol were synthesized. A neutral permanganate oxidation of noracetylmethadol gave a nitroalkane. This unusual oxidation product was readily converted to the primary amine metabolite of acetylmetha
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