1416816-01-7

Basic information

• Product Name: 6-(4-chloro-benzyl)-phenanthridine
• Synonyms: 6-(4-chloro-benzyl)-phenanthridine
• CAS NO: 1416816-01-7
• Molecular Weight: 303.791
• Mol File: 1416816-01-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 6-(4-chloro-benzyl)-phenanthridine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-chloro-benzyl)-phenanthridine(1416816-01-7)
• EPA Substance Registry System: 6-(4-chloro-benzyl)-phenanthridine(1416816-01-7)

Safety Data

• Hazardous Substances Data: 1416816-01-7(Hazardous Substances Data)

Upstream product

• 5346-21-4 N-formyl-2-aminobiphenyl 
• 615-43-0 2-iodophenylamine 
• 90-41-5 2-phenylaniline 
• 52744-05-5 O-ethyl S-4-chlorobenzyl carbonodithioate 
• 3128-77-6 2-isocyanobiphenyl 
• 591-50-4 iodobenzene 
• 140-53-4 p-chlorobenzyl cyanide 
• 106-43-4 para-chlorotoluene 
• 98-80-6 phenylboronic acid 
• 1073-67-2 4-vinylbenzyl chloride 

Relevant articles and documents

Metal-Free Synthesis 6-Benzylphenanthridines via Radical Addition/Cyclization of 2-Isocyanobiphenyls

A simple and practical approach has been established for the synthesis of 6-benzylphenanthridines from benzylic hydrocarbons and 2-isocyanobiphenyls via C(sp 3)-H/C(sp 2)-H bond functionalization under metal-free condition. The reaction exhibits good functional group tolerance and delivers the target products in moderate to excellent yields. The preliminary mechanistic investigation revealed that a radical intermediate might be involved in this reaction.

Rapid synthesis of polysubstituted phenanthridines from simple aliphatic/aromatic nitriles and iodo arenes: Via Pd(ii) catalyzed domino C-C/C-C/C-N bond formation

An efficient and straightforward method has been developed for the synthesis of polysubstituted phenanthridines from simple aryl iodides and alkyl/aryl nitriles via the palladium-catalyzed nucleophilic addition of aryl iodides to nitriles followed by casc

Free-amine-directed alkenylation of C(sp2)-H and cycloamination by palladium catalysis

A new protocol for the palladium-catalyzed free-amine-directed alkenylation of C(sp2)-H bonds and cycloamination is described. Substituted biaryl-2-amines react with various alkenes, including electron-deficient alkenes, aryl alkenes and alkyl alkenes, to give the corresponding phenanthridines with exclusive regioselectivity. The use of α-branched styrenes leads to the formation of tricyclic compounds with a seven-membered amine ring. The method operates through a free-amine-directed alkenylation and a subsequent hydroamination cyclization reaction. Seven-membered cycloamination: A new protocol for the palladium-catalyzed free-amine-directed alkenylation of C(sp2)-H bonds and subsequent cycloamination is described (see scheme). Substituted biaryl-2-amines react with various alkenes to give the corresponding phenanthridines with exclusive regioselectivity. The use of α-branched styrenes leads to the formation of tricyclic compounds with a seven-membered amine ring. Copyright