5346-21-4

Basic information

• Product Name: N-Biphenyl-2-yl-forMaMide
• Synonyms: N-Biphenyl-2-yl-forMaMide
• CAS NO: 5346-21-4
• Molecular Formula: C₁₃H₁₁NO
• Molecular Weight: 197.23254
• Mol File: 5346-21-4.mol
• Article Data: 48

Chemical Properties

• Melting Point: 67-70 °C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• PKA: 14.76±0.70(Predicted)
• CAS DataBase Reference: N-Biphenyl-2-yl-forMaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Biphenyl-2-yl-forMaMide(5346-21-4)
• EPA Substance Registry System: N-Biphenyl-2-yl-forMaMide(5346-21-4)

Safety Data

• Hazardous Substances Data: 5346-21-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H17N2OS.BrH/c1-3-14(4-2)13(16)9-15-10-17-12-8-6-5-7-11(12)15;/h5-8,10H,3-4,9H2,1-2H3;1H/q+1;/p-1

Upstream product

• 64-18-6 formic acid 
• 90-41-5 2-phenylaniline 
• 2258-42-6 formyl acetic anhydride 
• 615-36-1 2-bromoaniline 
• 98-80-6 phenylboronic acid 
• 86-00-0 2-nitrobiphenyl 
• 124-38-9 carbon dioxide 
• 108-24-7 acetic anhydride 
• 144-62-7 oxalic acid 
• 68-12-2 N,N-dimethyl-formamide 
• 123-91-1 1,4-dioxane 
• 615-43-0 2-iodophenylamine 
• 109-94-4 formic acid ethyl ester 
• 2996-92-1 phenyl trimethylsiloxane 

Downstream Products

• 167889-01-2 N-(1-azabicyclo<3.3.0>octan-5-yl)methyl-N-formyl-2-phenylalanine 
• 229-87-8 phenanthridine 
• 90-41-5 2-phenylaniline 
• 2185-92-4 2-aminobiphenyl hydrochloride 
• 1378043-01-6 phenanthridin‐6‐yldiphenylphosphine oxide 
• 1416816-01-7 6-(4-chloro-benzyl)-phenanthridine 
• 16573-51-6 6-benzyl-phenanthridine 
• 66907-73-1 1-biphenyl-2-yl-1H-tetrazol-5-ylamine 
• 32317-23-0 N-([1,1'-biphenyl]-2-yl)-2-methylbenzamide 

Relevant articles and documents

Enantioselective Synthesis of Azetidines through [3 + 1]-Cycloaddition of Donor-Acceptor Aziridines with Isocyanides

The enantioselective [3 + 1]-cycloaddition of racemic donor-acceptor (D-A) aziridines with isocyanides was first realized under mild reaction conditions using a chiral N,N′-dioxide/MgIIcomplex as catalyst, providing a facile route to enantioenriched exo-imido azetidines with good to excellent yield (up to 99%) and enantioselectivity (up to 94% ee). An obvious chiral amplification effect was observed in this system, and an explanation was elucidated based on the experimental investigation and X-ray crystal structure of the enantiomerically pure catalyst.

Catalyst-free synthesis of phenanthridinesviaelectrochemical coupling of 2-isocyanobiphenyls and amines

Catalyst free synthesis of 6-aryl phenanthridines and amides through an electrochemical reaction is reported in this study. The coupling reaction proceeds by the cathodic reduction ofin situformed diazonium ions, which are formed from anilines and an alkyl nitrite. The generated aryl radical diazonium ions coupled from isocyanides furnished the desired products in good yields. This cascade reaction was conducted in an undivided cell equipped with an RVC as the anode and Pt as the cathode usingnBu4NBF4as the electrolyte at room temperature. A series of detailed mechanistic studies have also been performed, including a radical clock experiment and cyclic voltammetry analysis.

Copper promoted aerobic oxidative c(sp3)-c(sp3) bond cleavage of n-(2-(pyridin-2-yl)-ethyl)anilines

A strategy of aerobic oxidative C(sp3)-C(sp3) bond cleavage of N-ethylaniline derivatives bearing azaarenes for the synthesis of N-aryl formamides has been developed. This approach was carried out smoothly with the CuI/TEMPO/air system to give N-aryl formamides in yields of 50-90%. With this methodology, a mutagenically active compound was constructed in 90% yield. Moreover, the reaction also provided a one-pot synthetic tool for accessing a promoter of hematopoietic stem cells by difunctionalization in 61% yield.