14337-31-6

Basic information

• Product Name: BenzeneMethanol, 4-Methoxy-.alpha.-(trichloroMethyl)-
• Synonyms: BenzeneMethanol, 4-Methoxy-.alpha.-(trichloroMethyl)-;2,2,2-Trichloro-1-(4-methoxyphenyl)ethanol
• CAS NO: 14337-31-6
• Molecular Formula: C₉H₉Cl₃O₂
• Molecular Weight: 255.52556
• Mol File: 14337-31-6.mol
• Article Data: 21

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BenzeneMethanol, 4-Methoxy-.alpha.-(trichloroMethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: BenzeneMethanol, 4-Methoxy-.alpha.-(trichloroMethyl)-(14337-31-6)
• EPA Substance Registry System: BenzeneMethanol, 4-Methoxy-.alpha.-(trichloroMethyl)-(14337-31-6)

Safety Data

• Hazardous Substances Data: 14337-31-6(Hazardous Substances Data)

Usage

Description

BenzeneMethanol, 4-Methoxy-α-(trichloroMethyl)-, also known as 2,2,2-Trichloro-1-(4-methoxyphenyl)ethanol, is an organic compound that serves as an intermediate in the synthesis of various chemicals. It is characterized by its unique molecular structure, which includes a benzene ring with a methoxy group and a trichloromethyl group attached to a central carbon atom bonded to a hydroxyl group.

Uses

Used in Pesticide Synthesis:
BenzeneMethanol, 4-Methoxy-α-(trichloroMethyl)is used as an intermediate in the synthesis of Methoxy-DDT (M260800), a metabolite of 4,4''-Dichlorodiphenyltrichloroethane (D434195). This synthetic organochlorine insecticide is effective in controlling insect populations due to its mode of action, which involves opening sodium ion channels in the insects' neurons. This causes the neurons to fire spontaneously, ultimately leading to the death of the insect.
In the Chemical Industry:
BenzeneMethanol, 4-Methoxy-α-(trichloroMethyl)is used as a key component in the production of various chemicals and pharmaceuticals. Its unique structure allows it to be a versatile building block for the synthesis of a wide range of compounds, making it valuable in the development of new products and applications within the chemical industry.

Upstream product

• 67-66-3 chloroform 
• 123-11-5 4-methoxy-benzaldehyde 
• 75-87-6 chloral 
• 100-66-3 methoxybenzene 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 302-17-0 chloral hydrate 
• 7294-51-1 2,4,6-tris(4-methoxyphenyl)boroxine 
• 105-13-5 4-Methoxybenzyl alcohol 
• 650-51-1 sodium trichloroacetate 
• 77-78-1 dimethyl sulfate 
• 76-03-9 trichloroacetic acid 
• 56-23-5 tetrachloromethane 
• 14202-31-4 4-methoxybenzaldehyde-1,1-diacetate 

Downstream Products

• 34197-08-5 2-(4-ethoxy-phenyl)-1,1,1-trichloro-2-(4-methoxy-phenyl)-ethane 
• 54034-89-8 [2,2,2-trichloro-1-(4-methoxyphenyl)ethoxy]trimethylsilane 
• 78401-33-9 1-(1-Allyloxy-2,2,2-trichloro-ethyl)-4-methoxy-benzene 
• 41448-64-0 1-(2,2-dichlorovinyl)-4-methoxybenzene 
• 58622-56-3 α-(dichloromethyl)-4-methoxybenzenemethanol 
• 81928-73-6 1-(2,2-Dichloro-1-isopropoxy-ethyl)-4-methoxy-benzene 
• 62688-84-0 1-methoxy-4-(2,2,2-trichloro-1-methoxy-ethyl)-benzene 
• 59424-74-7 1-Butoxy-2,5-diisopropyl-4-[2,2,2-trichloro-1-(4-methoxy-phenyl)-ethyl]-benzene 
• 123-11-5 4-methoxy-benzaldehyde 
• 52126-73-5 C₁₇H₁₇Cl₃OS 
• 20714-90-3 4-Methoxymandelic acid 
• 67-66-3 chloroform 
• 100-09-4 4-methoxybenzoic acid 
• 29003-60-9 2,2-dichloro-4'-methoxyacetophenone 

Relevant articles and documents

General and Efficient Synthesis of 1,1,1-Trichloro-2-alkanols

1,1,1-Trichloroalkanols were readily obtained in good yields by reaction of trichloroacetic acid with aldehydes in hexamethylphosphoric triamide. 1,3-Dimethyl-2-imidazolidinone was found to be useful as an alternate solvent giving, however, lower yields.

PESTICIDAL COMPOUNDS AND METHODS OF USE

Described herein are compounds, pesticidally acceptable salts thereof, and compositions thereof that are useful, for example, for pest management and for controlling pests. In certain embodiments provided are enantioenriched and/or enantiopure compounds and pesticidally acceptable salts thereof, and methods of making same. Methods of controlling pests with the compounds of the disclosure are also provided.

One-Carbon Homologation of Primary Alcohols and the Reductive Homologation of Aldehydes Involving a Jocic-Type Reaction

(Trichloromethyl)carbinols, which are formed in one operation from either alcohols or aldehydes, can be converted into primary alcohols in a Jocic-type reaction involving LiBH4. The net result is a convenient two-step, one-carbon homologation of primary alcohols or a reductive one-carbon homologation of aldehydes featuring a broad substrate scope. The method is step-economical, and it nicely complements established one-carbon homologation strategies. (Trichloromethyl)carbinols, which are formed in one operation from either alcohols or aldehydes, can be converted into primary alcohols in a Jocic-type reaction involving LiBH4. The net result is a convenient two-step, one-carbon homologation of primary alcohols or a reductive one-carbon homologation of aldehydes featuring a broad substrate scope.