29003-60-9

Basic information

• Product Name: Ethanone, 2,2-dichloro-1-(4-methoxyphenyl)- (9CI)
• Synonyms: Ethanone, 2,2-dichloro-1-(4-methoxyphenyl)- (9CI)
• CAS NO: 29003-60-9
• Molecular Formula: C₉H₈Cl₂O₂
• Molecular Weight: 219.06462
• Product Categories: ACETYLHALIDE
• Mol File: 29003-60-9.mol
• Article Data: 23

Chemical Properties

• Melting Point: 77–78°C
• Appearance: /
• CAS DataBase Reference: Ethanone, 2,2-dichloro-1-(4-methoxyphenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2,2-dichloro-1-(4-methoxyphenyl)- (9CI)(29003-60-9)
• EPA Substance Registry System: Ethanone, 2,2-dichloro-1-(4-methoxyphenyl)- (9CI)(29003-60-9)

Safety Data

• Hazardous Substances Data: 29003-60-9(Hazardous Substances Data)

Usage

Preparation

Preparation by treatment of anisole with benzyltrimethylammonium tetrachlor-oiodate (BTMA ICl4) in acetic acid at 70° for 5 h (78%)Also obtained by reaction of anisole with dichloroacetyl chloride in the presence of aluminium chloride.

Upstream product

• 79-36-7 dichloroacethyl chloride 
• 100-66-3 methoxybenzene 
• 86002-03-1 2-Benzenesulfinyl-2,2-dichloro-1-(4-methoxy-phenyl)-ethanol 
• 64-19-7 acetic acid 
• 768-60-5 4-methoxyphenylacetylen 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 123-11-5 4-methoxy-benzaldehyde 
• 14337-31-6 2,2,2-trichloro-1-(4-methoxyphenyl)ethan-1-ol 
• 36458-91-0 2,2,2-trichloro-1-(4-methoxyphenyl)ethan-1-one 
• 3672-47-7 3-oxo-3-(4'-methoxyphenyl)propanenitrile 
• 94-30-4 ethyl 4-methoxybenzoate 
• 100-09-4 4-methoxybenzoic acid 
• 3179-10-0 1-methoxy-4-(2-nitro-vinyl)-benzene 

Downstream Products

• 7099-91-4 p-methoxybenzoylformic acid 
• 58622-56-3 α-(dichloromethyl)-4-methoxybenzenemethanol 
• 36458-91-0 2,2,2-trichloro-1-(4-methoxyphenyl)ethan-1-one 
• 100-09-4 4-methoxybenzoic acid 
• 79881-24-6 1,4-bis(4-methoxyphenyl)-2,2,3,3-tetrachloro-1,4-butanedione 
• 2132-70-9 1,1-dichloro-2,2-bis(p-methoxyphenyl)ethylene 
• 79881-28-0 1,4-bis(4-methoxyphenyl)-2,3-dichloro-2-butene-1,4-dione 
• 15982-64-6 1,4-bis(4-methoxyphenyl)butane-1,4-dione 
• 7465-87-4 N-benzyl-4-methoxybenzamide 
• 126679-87-6 N-benzyl-N’-(4-methoxyphenyl)urea 
• 3532-17-0 4-methoxybenzoyl azide 

Relevant articles and documents

Method for preparing alpha,alpha-dihalogenated acetophenone compound

The invention belongs to the technical field of organic synthesis and in particular relates to a method for preparing an alpha,alpha-dihalogenated acetophenone compound. The preparation method provided by the invention comprises the following steps: in an alcohol solvent, enabling nitroalkenes, electrophilic halogen reagents and sodium hydride to react at 55-65 DEG C under a heating condition for5-10 hours, cooling the components to the room temperature, adding a diluted acid solution, and performing continue stirring for 2-5 hours, so as to obtain a target compound, namely alpha,alpha-dihalogenated acetophenone. The method for preparing the alpha,alpha-dihalogenated acetophenone compound, which is provided by the invention, is simple and efficient, mild in condition, easy in raw materialobtaining, green and environment-friendly and simple and convenient to operate, and as a synthesis intermediate, the obtained alpha,alpha-dihalogenated acetophenone compound has the potential of being widely used in fields such as medicine chemical engineering.

Method for removal of methanamide by dichlorination

A method for removal of methanamide by dichlorination is disclosed, according to the method, a finished product is obtained by removal of methanamide by dichlorination by one-step-reaction of various beta-carbonyl amide derivatives as raw materials, 2,2,6,6-Tetramethylpiperidinooxy (TEMPO) and an alkali as additives and N-chlorosuccinimide as a reagent in a reaction solvent, and then concentration and purification. According to the method, synthesis of an alpha-dichloroacetophenone derivative can be realized for the first time by a method of removal of methanamide by fracturation of carbon-carbon single bond. The method is novel and unique, has certain universality, is mild in reaction conditions, low in requirement of production equipment, and simple in technology, has the advantages of high efficiency, simple operation, high safety, economy and environmentally-friendliness; high-quality diverse alpha-dichloroacetophenone derivative products can be prepared by the method, and the products prepared by the method are important drug synthesis intermediates and material intermediates, can be widely used in the synthesis of heterocycles, unsaturated acids, acetylene alcohols and other compounds and cyclopropanation, and have wide market prospects.