1443749-27-6

Basic information

• Product Name: C₄₁H₄₂Cl₂FN₃O₄
• CAS NO: 1443749-27-6
• Molecular Weight: 730.707
• Mol File: 1443749-27-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₁H₄₂Cl₂FN₃O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₁H₄₂Cl₂FN₃O₄(1443749-27-6)
• EPA Substance Registry System: C₄₁H₄₂Cl₂FN₃O₄(1443749-27-6)

Safety Data

• Hazardous Substances Data: 1443749-27-6(Hazardous Substances Data)

Upstream product

• 897365-81-0 (3S,3'S,4'R,6'R,8'S,8a'R)-6-chloro-8'-(3-chloro-2-fluorophenyl)-6'-neopentyl-3',4'-diphenyl-3',4',8',8a'-tetrahydrospiro[indoline-3,7'-pyrrolo[2,1-c][1,4]oxazine]-1',2(6'H)-dione 
• 1036260-43-1 cis-3-aminocyclobutanol 

Downstream Products

• 1303605-90-4 MI-519-63 
• 1443749-21-0 (2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-N-(cis-3-hydroxycyclobutyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxamide 

Relevant articles and documents

A potent small-molecule inhibitor of the MDM2-p53 interaction (MI-888) achieved complete and durable tumor regression in mice

We previously reported the discovery of a class of spirooxindoles as potent and selective small-molecule inhibitors of the MDM2-p53 interaction (MDM2 inhibitors). We report herein our efforts to improve their pharmacokinetic properties and in vivo antitumor activity. Our efforts led to the identification of 9 (MI-888) as a potent MDM2 inhibitor (Ki = 0.44 nM) with a superior pharmacokinetic profile and enhanced in vivo efficacy. Compound 9 is capable of achieving rapid, complete, and durable tumor regression in two types of xenograft models of human cancer with oral administration and represents the most potent and efficacious MDM2 inhibitor reported to date.