149507-31-3

Basic information

• Product Name: Carbamic acid, [3-(phenylmethoxy)phenyl]-, 1,1-dimethylethyl ester
• CAS NO: 149507-31-3
• Molecular Formula: C18H21NO3
• Molecular Weight: 299.37
• Mol File: 149507-31-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [3-(phenylmethoxy)phenyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [3-(phenylmethoxy)phenyl]-, 1,1-dimethylethyl ester(149507-31-3)
• EPA Substance Registry System: Carbamic acid, [3-(phenylmethoxy)phenyl]-, 1,1-dimethylethyl ester(149507-31-3)

Safety Data

• Hazardous Substances Data: 149507-31-3(Hazardous Substances Data)

Upstream product

• 591-20-8 3-Bromophenol 
• 53087-13-1 3-(benzyloxy)phenyl bromide 
• 4248-19-5 tert-butyl carbazate 
• 100-39-0 benzyl bromide 
• 19962-06-2 tert-butyl 3-hydroxyphenylcarbamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1484-26-0 3-(benzyloxy)aniline 
• 107826-08-4 3-azidophenyl benzyl ether 

Downstream Products

• 119879-92-4 5-(benzyloxy)-2-bromo-N-((tert-butyloxy)carbonyl)aniline 
• 1484-26-0 3-(benzyloxy)aniline 
• 849433-03-0 C₅₂H₅₃NO₇Si 
• 849433-05-2 C₅₃H₅₅NO₇Si 
• 849433-04-1 C₄₇H₄₁NO₇ 
• 849432-96-8 C₄₆H₃₉NO₆ 
• 849433-02-9 C₄₂H₅₁NO₇Si 
• 849433-01-8 C₃₄H₄₄INO₅Si 
• 849432-95-7 C₃₆H₃₇NO₆ 
• 849432-94-6 C₂₈H₃₀INO₄ 
• 849432-99-1 C₂₈H₃₀BrNO₅ 
• 849432-93-5 C₂₁H₂₄INO₄ 
• 849432-92-4 C₂₁H₂₃I₂NO₃ 
• 849432-91-3 C₂₁H₂₄BrNO₃ 

Relevant articles and documents

Substituted diarylurea derivative as well as preparation method and application thereof

The invention relates to a substituted diarylurea derivative as well as preparation and application thereof. Specifically, the invention discloses a compound with a formula (I) or an optical isomer, a cis-trans-isomer or a pharmaceutically acceptable salt thereof, and a preparation method thereof, wherein the definition of each substituent group in the general formula is described in the specification and claims. The invention further discloses a composition containing the compound and application of the composition. The compound disclosed by the invention has excellent anti-cancer activity on HepG2 liver cancer cells, MGC 803 gastric cancer cells, MCF 7 breast cancer cells and the like, and has a good inhibition effect on the growth of human umbilical vein endothelial cells (HUVEC).

Novel Deazaflavin Analogues Potently Inhibited Tyrosyl DNA Phosphodiesterase 2 (TDP2) and Strongly Sensitized Cancer Cells toward Treatment with Topoisomerase II (TOP2) Poison Etoposide

Topoisomerase II (TOP2) poisons as anticancer drugs work by trapping TOP2 cleavage complexes (TOP2cc) to generate DNA damage. Repair of such damage by tyrosyl DNA phosphodiesterase 2 (TDP2) could render cancer cells resistant to TOP2 poisons. Inhibiting TDP2, thus, represents an attractive mechanism-based chemosensitization approach. Currently known TDP2 inhibitors lack cellular potency and/or permeability. We report herein two novel subtypes of the deazaflavin TDP2 inhibitor core. By introducing an additional phenyl ring to the N-10 phenyl ring (subtype 11) or to the N-3 site of the deazaflavin scaffold (subtype 12), we have generated novel analogues with considerably improved biochemical potency and/or permeability. Importantly, many analogues of both subtypes, particularly compounds 11a, 11e, 12a, 12b, and 12h, exhibited much stronger cancer cell sensitizing effect than the best previous analogue 4a toward the treatment with etoposide, suggesting that these analogues could serve as effective cellular probes.

The Lindlar Catalyst Revitalized: A Highly Chemoselective Method for the Direct Conversion of Azides to N-(tert-Butoxycarbonyl)amines

An exceptionally chemoselective method for the direct conversion of azides to N-(tert-butoxycarbonyl)-protected amines under catalytic transfer-hydrogenation conditions, using the Lindlar catalyst, is reported. The extremely labile functional groups such as N-Cbz, benzyl ester are shown to be inert under the reaction conditions. The present method allows us to synthesize orthogonally protected (N-Cbz and N-Boc) 1,2-diamino systems, which will be immensely useful in organic synthesis.