15115-52-3

Basic information

• Product Name: 4-BROMO-1-PHENYL-1H-PYRAZOLE
• Synonyms: 4-BROMO-1-PHENYL-1H-PYRAZOLE;4-Bromo-1-phenyl-1H-pyrazole 98%;4-bromo-1-phenylpyrazole
• CAS NO: 15115-52-3
• Molecular Formula: C₉H₇BrN₂
• Molecular Weight: 223.07
• Product Categories: Azoles;blocks;Bromides
• Mol File: 15115-52-3.mol
• Article Data: 12

Chemical Properties

• Melting Point: 78-79 °C
• Boiling Point: 296.238 °C at 760 mmHg
• Flash Point: 132.96 °C
• Appearance: /
• Density: 1.503 g/cm³
• Vapor Pressure: 0.00256mmHg at 25°C
• Refractive Index: 1.64
• Storage Temp.: 2-8°C
• PKA: -1.34±0.10(Predicted)
• CAS DataBase Reference: 4-BROMO-1-PHENYL-1H-PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-1-PHENYL-1H-PYRAZOLE(15115-52-3)
• EPA Substance Registry System: 4-BROMO-1-PHENYL-1H-PYRAZOLE(15115-52-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 15115-52-3(Hazardous Substances Data)

Usage

Description

4-BROMO-1-PHENYL-1H-PYRAZOLE is an organic compound with the molecular formula C9H7BrN2. It is a derivative of 1H-pyrazole, featuring a bromo and phenyl group attached to the 4th and 1st positions, respectively. 4-BROMO-1-PHENYL-1H-PYRAZOLE is known for its potential applications in the pharmaceutical and chemical industries due to its unique structural properties.

Uses

Used in Pharmaceutical Industry:
4-BROMO-1-PHENYL-1H-PYRAZOLE is used as a key intermediate in the synthesis of canagliflozin aryl C-glucoside with a thiophene ring. 4-BROMO-1-PHENYL-1H-PYRAZOLE serves as a sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor, which is crucial for the treatment of type 2 diabetes mellitus. By inhibiting SGLT2, it helps to reduce glucose absorption in the body, thereby managing blood sugar levels in patients with type 2 diabetes.

InChI:InChI=1/C9H7BrN2/c10-8-6-11-12(7-8)9-4-2-1-3-5-9/h1-7H

Upstream product

• 20638-31-7 4-bromo-1-phenyl-1H-pyrazole-3,5-dicarboxylic acid 
• 59360-06-4 α-bromo-β-anilineacrolein 
• 64-19-7 acetic acid 
• 100-63-0 phenylhydrazine 
• 2075-45-8 4-bromo-1H-pyrazole 
• 98-80-6 phenylboronic acid 
• 71-43-2 benzene 
• 591-50-4 iodobenzene 
• 56-23-5 tetrachloromethane 
• 1134-50-5 4-carboxy-1-phenylpyrazole 
• 7726-95-6 bromine 
• 54605-72-0 1-phenyl-1H-pyrazole-4-carbaldehyde 
• 58668-67-0 3-anilino-2-bromo-acrylaldehyde 
• 19263-02-6 2-bromo-3-hydroxypropenal 

Downstream Products

• 51039-46-4 3,4,5-tribromo-1-phenyl-1H-pyrazole 
• 15754-94-6 4-bromo-1-(4-bromophenyl)pyrazole 
• 3968-48-7 4-benzoyl-1-phenyl-1H-pyrazole 
• 1330767-33-3 4-(1,2-dimethyl-1H-imidazol-5-yl)-1-phenyl-1H-pyrazole 
• 1330767-37-7 4-methyl-5-(1-phenyl-1H-pyrazol-4-yl)thiazole 
• 1330767-29-7 4-(1-methyl-1H-imidazol-5-yl)-1-phenyl-1H-pyrazole 
• 1002334-12-4 1-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 
• 1126-00-7 1-phenylpyrazole 
• 18830-03-0 1,1'-diphenyl-1H,1'H-4,4'-bipyrazole 
• 95881-82-6 6,6′-dimethoxy-3,3′-bipyridine 
• 2132-80-1 4,4'-Dimethoxybiphenyl 
• 65480-21-9 1-Phenylphenanthro[9,10-d]pyrazole 
• 1128-53-6 1-phenyl-1H-pyrazol-4-amine 

Relevant articles and documents

A fast and efficient bromination of isoxazoles and pyrazoles by microwave irradiation

A fast and efficient method has been developed for the bromination of isoxazoles and pyrazoles using microwave irradiation. In this method, N-bromosuccinimide was used in different acid solvents according to the reactivity of the substrates to give mono-b

Unveiling Potent Photooxidation Behavior of Catalytic Photoreductants

We describe a photocatalytic system that reveals latent photooxidant behavior from one of the most reducing conventional photoredox catalysts, N-phenylphenothiazine (PTH). This aerobic photochemical reaction engages difficult to oxidize feedstocks, such as benzene, in C(sp2)-N coupling reactions through direct oxidation. Mechanistic studies are consistent with activation of PTH via photooxidation and with Lewis acid cocatalysts scavenging inhibitors inextricably formed in this process.

Framework-Copper-Catalyzed C?N Cross-Coupling of Arylboronic Acids with Imidazole: Convenient and Ligand-Free Synthesis of N-Arylimidazoles

A convenient and environmentally benign synthesis of N-arylimidazoles has been demonstrated by a straightforward reaction catalyzed by the unsaturated coordination sites of Cu in the copper terephthalate metal–organic framework (Cu(tpa)-MOF). A series of N-arylimidazoles has been synthesized in excellent yields by the C?N cross-coupling reaction of arylboronic acids and imidazoles catalyzed by the Cu(tpa)-MOF using ethanol as a benign solvent. The present ligand-free catalytic system proceeds smoothly under mild conditions, avoids stoichiometric Cu reagents, tolerates many functional groups, has a wide substrate scope, and is feasible with other nitrogen heterocycles. The stability and heterogeneity of the catalyst is evidenced by the results of a heterogeneity test, and the catalyst can be reused several times without a loss of activity. The easy preparation of the catalyst, its stability, recovery by simple filtration, and reusability reveal Cu(tpa) MOF as a versatile catalyst for academic and industrial applications.