152298-57-2Relevant articles and documents
AMINO ACID DERIVATIVES
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Page column 2, (2010/01/30)
There is provided amino acid derivatives of formula I, wherein p, q, R 1, R 2, R 3, R 4, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
Quaternary ammonium salts of aromatic amine compounds, their preparation and pharmaceutical compositions in which they are present
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, (2008/06/13)
The present invention relates to quaternary ammonium salts of the formula STR1 in which: J is either a group Ar--CXX''--CX"" or a group Ar--(CH 2) x CH 1, in which:Ar is a substituted or unsubstituted phenyl, a cycloalkyl, a pyridyl or a thienyl;X is hydrogen;X'' is hydrogen or is combined with X"" below to form a carbon-carbon bond, or else X and X'' together form an oxo group;X"" is hydrogen or forms a carbon-carbon bond with X'';X is zero or one; andX 1 is hydrogen (n=0), a hydroxyl, an alkoxy, an acyloxy, a carboxyl, a carbalkoxy, a cyano or an alkoxyamino group;Q is an alkyl group or a benzyl group;A is an anion;m is 2 or 3;Ar'', R, T and Z are as defined in the specification, are neurokinin receptor antagonists.