17119-15-2

Basic information

• Product Name: 3-HYDROXYMANDELIC ACID
• Synonyms: 3-HYDROXYMANDELIC ACID;M-HYDROXYMANDELIC ACID;3-hydroxyphenylglycolic acid;2-hydroxy-2-(3-hydroxyphenyl)acetic acid;3,α-Dihydroxybenzeneacetic acid;α,3-Dihydroxybenzeneacetic acid;alpha,3-Dihydroxybenzeneacetic acid;Einecs 241-182-3
• CAS NO: 17119-15-2
• Molecular Formula: C₈H₈O₄
• Molecular Weight: 168.15
• EINECS: 241-182-3
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Aromatics Compounds;Aromatics;C8;Carbonyl Compounds;Carboxylic Acids
• Mol File: 17119-15-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 128-132 °C
• Boiling Point: 424.3°Cat760mmHg
• Flash Point: 224.5°C
• Appearance: /
• Density: 1.48g/cm³
• Vapor Pressure: 5.91E-08mmHg at 25°C
• Refractive Index: 1.637
• Storage Temp.: -20°C Freezer
• Solubility: Acetonitrile (Slightly), Methanol (Slightly)
• PKA: 3.36±0.10(Predicted)
• BRN: 2365378
• CAS DataBase Reference: 3-HYDROXYMANDELIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-HYDROXYMANDELIC ACID(17119-15-2)
• EPA Substance Registry System: 3-HYDROXYMANDELIC ACID(17119-15-2)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 17119-15-2(Hazardous Substances Data)

Usage

Description

3-Hydroxymandelic Acid, also known as 3-Hydroxymandelic Acid (CAS# 17119-15-2), is a hydroxy acid derivative with a chemical structure that features a 2-hydroxy monocarboxylic acid with a hydroxy group substitution at the 3' position. It is an off-white powder and has been successfully separated into its chiral forms using ligand-exchange capillary electrochromatography.

Uses

Used in Organic Synthesis:
3-Hydroxymandelic Acid is used as an intermediate in the synthesis of various organic compounds. Its unique chemical structure allows it to be a versatile building block for the creation of a wide range of molecules, making it valuable in the field of organic chemistry.
Used in Pharmaceutical Industry:
3-Hydroxymandelic Acid is used as a starting material for the synthesis of various pharmaceutical compounds. Its ability to be modified and incorporated into different molecular structures makes it a valuable asset in the development of new drugs and therapeutic agents.
Used in Chemical Research:
3-Hydroxymandelic Acid is used as a research compound in the study of various chemical reactions and processes. Its unique properties and reactivity make it an interesting subject for scientists to explore and understand, potentially leading to new discoveries and advancements in the field of chemistry.

InChI:InChI=1/C8H8O4/c9-6-3-1-2-5(4-6)7(10)8(11)12/h1-4,7,9-10H,(H,11,12)/t7-/m1/s1

Upstream product

• 102654-39-7 ethyl 3-hydroxymandelate 
• 19473-06-4 Sodium; hydroxy-(3-hydroxy-phenyl)-methanesulfonate 
• 611-71-2 MANDELIC ACID 
• 53313-95-4 α,3-dihydroxybenzeneacetonitrile 

Downstream Products

• 100-83-4 meta-hydroxybenzaldehyde 
• 99-06-9 3-Carboxyphenol 
• 53623-77-1 m-hydroxymandelic acid 
• 1360460-68-9 1-(3α-((10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)oxy)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxy-2-(3-hydroxyphenyl)ethanone 
• 152298-57-2 (3-isopropoxyphenyl)hydroxyacetic acid 
• 51777-12-9 (6R)-3-acetoxymethyl-7t-[(Ξ)-2-hydroxy-2-(3-hydroxy-phenyl)-acetylamino]-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; triethylamine salt 

Relevant articles and documents

Mutasynthesis of Glycopeptide Antibiotics: Variations of Vancomycin's AB-Ring Amino Acid 3,5-Dihydroxyphenylglycine

In the mutasynthetic approach, the ΔdpgA mutant of the vancomycin-type glycopeptide antibiotic producer Amycolatopsis balhimycina, which is deficient in the synthesis of 3,5-dihydroxyphenylglycine (DPg), was supplemented with synthetic DPg analogues to obtain the corresponding modified glycopeptides. Sterically more demanding 3,5-disubstituted methoxy derivatives as well as monosubstituted DPg analogues were accepted as substrates. These facts indicate that steric and electronic requirements suffice in several cases for the oxidative closure of the AB ring, thus leading to the generation of novel antibiotically active glycopeptide derivatives. The results represent a further step in evaluating the potential of mutasynthesis for peptidic secondary metabolites. Copyright

7-α-Amino-substituted acylamino-3-(1-carboxymethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acids

Certain 7-acylamido-3-(1-carboxy-loweralkyl-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acids and their salts and easily hydrolyzed esters of the 4-carboxyl group were synthesized and found to be potent antibacterial agents which exhibited good aqueous solubility. In a preferred embodiment the 7-substituent was 2'-aminomethylphenylacetamido.

7-(D-α-Hydroxy-2-arylacetamido)-3-(tetrazolo-[4,5-b]pyridazin-6-ylthiomethyl)-3-cephem-4-carboxylic acids

7-(D-α-Hydroxy-2-arylacetamido)-3-(tetrazolo-[4,5-b]pyridazin-6-ylthiomethyl)-3-cephem-4-carboxylic acids and their nontoxic, pharmaceutically acceptable salts are valuable as antibacterial agents and are particularly valuable as therapeutic agents in poultry and animals, including man, in the treatment of infectious diseases caused by many Gram-positive and Gram-negative bacteria.