1618665-84-1Relevant articles and documents
Organotin(IV)-loaded mesoporous silica as a biocompatible strategy in cancer treatment
Bulatovic, Mirna Z.,Maksimovic-Ivanic, Danijela,Bensing, Christian,Gomez-Ruiz, Santiago,Steinborn, Dirk,Schmidt, Harry,Mojic, Marija,Korac, Aleksandra,Golic, Igor,Perez-Quintanilla, Damian,Momcilovic, Miljana,Mijatovic, Sanja,Kaluderovic, Goran N.
, p. 5982 - 5987 (2014)
The strong therapeutic potential of an organotin(IV) compound loaded in nanostructured silica (SBA-15pSn) is demonstrated: B16 melanoma tumor growth in syngeneic C57BL/6 mice is almost completely abolished. In contrast to apoptosis as the basic mechanism of the anticancer action of numerous chemotherapeutics, the important advantage of this SBA-15pSn mesoporous material is the induction of cell differentiation, an effect unknown for metal-based drugs and nanomaterials alone. This non-aggressive mode of drug action is highly efficient against cancer cells but is in the concentration range used nontoxic for normal tissue. JNK (Jun-amino-terminal kinase)-independent apoptosis accompanied by the development of the melanocyte-like nonproliferative phenotype of survived cells indicates the extraordinary potential of SBA-15pSn to suppress tumor growth without undesirable compensatory proliferation of malignant cells in response to neighboring cell death. More than packaging: When a nanostructured material is loaded with an organotin(IV) compound, the efficacy of the anticancer drug is amplified dramatically. The loaded nanomaterial almost completely abolished tumor growth in syngeneic C57BL/6 mice. The reversion of the cancer cells to the normal phenotype is highly compatible with the surrounding tissue and presents a very safe mechanism for fighting cancer.
