16603-18-2 Usage
Description
3,4,5-Trimethoxyphenylacetone, also known as Vanillin Acetate, is a phenylacetone derivative with a molecular formula of C12H16O4. It is a clear, colorless to yellowish liquid characterized by a sweet, floral odor. This chemical compound is widely recognized for its applications in the food industry, particularly as a flavoring agent in the production of vanilla flavoring, and has been studied for its potential antimicrobial and antioxidant properties. Furthermore, it plays a significant role in the synthesis of various pharmaceuticals and other organic compounds.
Uses
Used in the Food Industry:
3,4,5-Trimethoxyphenylacetone is used as a flavoring agent for its sweet, floral odor, primarily in the production of vanilla flavoring. Its ability to mimic the aroma and taste of natural vanilla makes it a valuable ingredient in the creation of a wide range of food products.
Used in Pharmaceutical Synthesis:
3,4,5-Trimethoxyphenylacetone serves as a key intermediate in the synthesis of various pharmaceuticals and organic compounds. Its unique chemical structure allows it to be a versatile building block in the development of new drugs and medicinal agents.
Used in Antimicrobial Applications:
3,4,5-Trimethoxyphenylacetone has been studied for its potential antimicrobial properties. Its ability to inhibit the growth of certain microorganisms makes it a candidate for use in applications where controlling microbial contamination is essential, such as in food preservation or medical settings.
Used in Antioxidant Applications:
3,4,5-Trimethoxyphenylacetone has also been investigated for its antioxidant properties. Its capacity to neutralize free radicals and protect against oxidative stress could make it a valuable component in products designed to promote health and prevent cellular damage.
Check Digit Verification of cas no
The CAS Registry Mumber 16603-18-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,6,0 and 3 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 16603-18:
(7*1)+(6*6)+(5*6)+(4*0)+(3*3)+(2*1)+(1*8)=92
92 % 10 = 2
So 16603-18-2 is a valid CAS Registry Number.
InChI:InChI=1/C12H16O4/c1-8(13)5-9-6-10(14-2)12(16-4)11(7-9)15-3/h6-7H,5H2,1-4H3
16603-18-2Relevant articles and documents
A convenient and efficient one-pot synthesis of arylacetones from (E)-3-aryl-2-methylacrylic acids by curtius rearrangement
He, Xin,Cao, Chong,Liang, Jingwei,Li, Xinyang,Zhang, Tingjian,Meng, Fanhao
, p. 386 - 390 (2017/02/10)
A convenient and efficient method was developed for the synthesis of arylacetones from (E)-3-aryl-2-methylacrylic acids through a Curtius rearrangement. The Curtius rearrangement of (E)-3-aryl-2-methylacryloyl azides and subsequent hydrolysis proceeded at mild temperatures in a two-phase medium of carbon tetrachloride and water containing a catalytic amount of tetrabutylammonium bromide to give the corresponding derivatives in 82-93% yield.
Addressing challenges in palladium-catalyzed cross-couplings of aryl mesylates: Monoarylation of ketones and primary alkyl amines
Alsabeh, Pamela G.,Stradiotto, Mark
supporting information, p. 7242 - 7246 (2013/07/26)
Mor(DalPhos) for Me(sylates): Described are the first examples of ketone mono-α-arylation and primary aliphatic amine monoarylation employing aryl methanesulfonate coupling partners. A range of functionalized aryl mesylates were employed with dialkyl ketones, and also with primary and secondary amines as well as the otherwise challenging coupling partners acetone and methylamine. Ad=adamantyl. Copyright
Fe-HCl: An efficient reagent for deprotection of oximes as well as selective oxidative hydrolysis of nitroalkenes and nitroalkanes to ketones
Pradhan, Prasun K.,Dey, Sumit,Jaisankar, Parasuraman,Giri, Venkatachalam S.
, p. 913 - 922 (2007/10/03)
Fe-HCl mixture was found to selectively perform oxidative hydrolysis of the nitroalkenes 1a-j and nitroalkanes 2a-j to the ketones 3a-j. Also, the reagent was observed to deprotect the oximes 7a-j to carbonyl compounds 8a-j in excellent yields.
