168013-75-0

Basic information

• Product Name: Benzeneacetonitrile, .alpha.-hydroxy-4-(trifluoromethyl)-
• Synonyms: Benzeneacetonitrile, .alpha.-hydroxy-4-(trifluoromethyl)-;Benzeneacetonitrile, a-hydroxy-4-(trifluoroMethyl)-
• CAS NO: 168013-75-0
• Molecular Formula: C₉H₆F₃NO
• Molecular Weight: 201
• Mol File: 168013-75-0.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Benzeneacetonitrile, .alpha.-hydroxy-4-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetonitrile, .alpha.-hydroxy-4-(trifluoromethyl)-(168013-75-0)
• EPA Substance Registry System: Benzeneacetonitrile, .alpha.-hydroxy-4-(trifluoromethyl)-(168013-75-0)

Safety Data

• Hazardous Substances Data: 168013-75-0(Hazardous Substances Data)

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 623-49-4 ethyl cyanoformate 
• 773837-37-9 sodium cyanide 
• 108-22-5 Isopropenyl acetate 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 151-50-8 potassium cyanide 
• 74-90-8 hydrogen cyanide 
• 73183-23-0 2-(4-(trifluoromethyl)phenyl)-2-((trimethylsilyl)oxy)acetonitrile 
• 4746-48-9 2-hydroxy-2,2-diphenylacetonitrile 
• 7677-24-9 trimethylsilyl cyanide 

Downstream Products

• 191720-36-2 (S)-2-hydroxy(4-trifluoromethylphenyl)acetonitrile 
• 149952-37-4 (R)-2-(4-fluorophenyl)-2-hydroxyacetonitrile 
• 124862-65-3 α-acetoxy-4-(trifluoromethyl)benzeneacetonitrile 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 80277-40-3 4-(trifluoromethyl)benzoyl cyanide 
• 455-24-3 4-trifluoromethylbenzoic acid 
• 1523301-56-5 2-((4-methoxyphenyl)amino)-2-(4-(trifluoromethyl)phenyl)acetonitrile 
• 167024-67-1 2-amino-2-(4-(trifluoromethyl)phenyl)acetonitrile 
• 720-76-3 5-(4-trifluoromethyl-phenyl)-4,5-dihydro-oxazol-2-ylamine 
• 156276-22-1 methyl 2-hydroxy-2-(4-(trifluoromethyl)phenyl)acetate 
• 81561-66-2 2-hydroxy-2-(4-trifluoromethylphenyl)ethanamine 

Relevant articles and documents

Constructing a triangular metallacycle with salen-Al and its application to a catalytic cyanosilylation reaction

A triangular metallosalen-based metallacycle was constructed in quantitative yield by the self-assembly of a 180° bis(pyridyl)salen-Al complex and a 60° diplatinum(ii) acceptor in a 1?:?1 stoichiometric ratio. This metallacycle was then successfully used to cyanosilylate a wide range of benzaldehydes with trimethylsilyl cyanide.

An orthogonal biocatalytic approach for the safe generation and use of HCN in a multistep continuous preparation of chiral O-acetylcyanohydrins

An enantioselective preparation of O-acetylcyanohydrins has been accomplished by a three-step telescoped continuous process. The modular components enabled an accurate control of two sequential biotransformations, safe handling of an in situ generated hazardous gas, and in-line stabilization of products. This method proved to be advantageous over the batch protocols in terms of reaction time (40 min vs 345 min) and ease of operation, opening up access to reactions which have often been neglected due to safety concerns.

Dibutyltin dimethoxide-catalyzed cyano transfer to aldehydes and imines

A novel reaction involving cyano transfer from benzophenone cyanohydrin to aldehydes and imines was realized by using dibutyltin dimethoxide as a catalyst. Various cyanohydrins and α-amino nitriles were obtained in moderate to high yields by this reaction. Ketimines also showed remarkable reactivity as cyano acceptors under conventional reaction conditions. This catalytic reaction was further applied to a three-component condensation reaction of aldehydes, aniline, and benzophenone cyanohydrin in the presence of Drierite. Copyright