1680184-59-1 Usage
Description
Afatinib iMpurity is a structural analogue of Afatinib (A355300), an aminocrotonylamino-substituted quinazoline derivative. It is primarily used for treating various types of cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.
Uses
Used in Pharmaceutical Industry:
Afatinib iMpurity is used as an active pharmaceutical ingredient for the development of cancer treatments and medications targeting diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder. Its unique structure allows it to effectively target and inhibit specific enzymes and pathways involved in cancer growth and progression, making it a valuable compound in the fight against various malignancies.
Used in Research and Development:
Afatinib iMpurity is also utilized in research and development for the discovery of new therapeutic agents and understanding the molecular mechanisms underlying cancer and related diseases. Its structural similarity to Afatinib makes it a useful tool for studying the effects of aminocrotonylamino-substituted quinazoline derivatives on biological systems and identifying potential new drug candidates.
Used in Quality Control and Standardization:
In addition to its applications in the pharmaceutical and research industries, Afatinib iMpurity is used in quality control and standardization processes to ensure the purity, potency, and consistency of Afatinib-based medications. This helps maintain the safety and efficacy of these drugs, providing patients with reliable and effective treatment options.
Check Digit Verification of cas no
The CAS Registry Mumber 1680184-59-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,8,0,1,8 and 4 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1680184-59:
(9*1)+(8*6)+(7*8)+(6*0)+(5*1)+(4*8)+(3*4)+(2*5)+(1*9)=181
181 % 10 = 1
So 1680184-59-1 is a valid CAS Registry Number.
1680184-59-1Relevant articles and documents
An alternative synthesis of the non-small cell lung carcinoma drug afatinib
Kovacevic, Tatjana,Mesic, Milan,Avdagic, Amir,Zegarac, Miroslav
, p. 4180 - 4182 (2018)
Afatinib (BIBW2992) is the anticancer drug developed by Boehringer Ingelheim. This work is reporting the synthesis of the afatinib using a new route by Ullmann-Goldberg reaction from corresponding 4-anilinoquinazoline iodide as the last step in the synthesis. This route was not described previously and it could be used for synthesis of afatinib analogues.
Preparation method of afatinib maleate
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Paragraph 0026; 0032; 0034; 0035; 0036, (2019/12/25)
The invention belongs to the technical field of medicine preparation, and particularly relates to a preparation method of afatinib maleate. The preparation method of the afatinib maleate comprises thefollowing steps: reacting N4-(3-chloro-4-fluorophenyl)-
Arab league law for nepal preparation method of the compound
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Paragraph 0052-0057; 0061, (2019/04/10)
The invention provides a novel preparation method of an afatinib compound. Raw materials and reagents used in the preparation method have the advantages of low cost, stable chemical property and convenience in long-term storage and the content of an impurity cis-isomer in the prepared afatinib compound is very low.
