191084-78-3

Basic information

• Product Name: (4-methoxyphenyl)[2-(2-phenyl-1,1,1-trifluoroethyl)] amine
• Synonyms: (4-methoxyphenyl)[2-(2-phenyl-1,1,1-trifluoroethyl)] amine
• CAS NO: 191084-78-3
• Molecular Weight: 281.277
• Mol File: 191084-78-3.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: (4-methoxyphenyl)[2-(2-phenyl-1,1,1-trifluoroethyl)] amine(CAS DataBase Reference)
• NIST Chemistry Reference: (4-methoxyphenyl)[2-(2-phenyl-1,1,1-trifluoroethyl)] amine(191084-78-3)
• EPA Substance Registry System: (4-methoxyphenyl)[2-(2-phenyl-1,1,1-trifluoroethyl)] amine(191084-78-3)

Safety Data

• Hazardous Substances Data: 191084-78-3(Hazardous Substances Data)

Upstream product

• 202869-51-0 4-methoxy-N-(2,2,2-trifluoro-1-phenylethylidene)benzenamine 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 1613-90-7 4-methoxy-N-[(E)-phenylmethylidene]aniline 
• 456-56-4 phenyl trifluoromethylsulfide 
• 783-08-4 [4-(benzylideneamino)phenyl]methanol 
• 434-45-7 2,2,2-Trifluoroacetophenone 
• 104-94-9 4-methoxy-aniline 
• 3262-89-3 triphenylboroxine 
• 1005385-31-8 N-(2,2,2-trifluoro-1-methoxyethyl)-4-methoxyaniline 
• 869653-41-8 C₁₅H₁₂F₃NO 
• 2101-87-3 p-methoxy-phenylazide 
• 14796-89-5 4-methoxy-N-(triphenylphosphoran-ylidene)-aniline 
• 17377-95-6 benzyl(4-methoxyphenyl)amine 
• 19064-76-7 N-benzylidene-4-methoxyaniline oxide 

Downstream Products

• 293743-63-2 N-(4-methoxyphenyl)-N-(1,1,1-trifluoro-2-phenethyl)-4-methoxybenzamide 
• 293743-65-4 N-(4-methoxyphenyl)-N-(1,1,1-trifluoro-2-phenethyl)-3-methoxybenzamide 
• 293743-66-5 N-(4-methoxyphenyl)-N-(1,1,1-trifluoro-2-phenethyl)-2-methoxybenzamide 
• 293743-64-3 N-(4-methoxyphenyl)-N-(1,1,1-trifluoro-2-phenethyl)-benzamide 

Relevant articles and documents

Novel and effective synthesis of trifluoromethylated amines by use of an Et3GeNa/C6H5SCF3 combination

Efficient synthesis of trifluoromethylated amine derivatives by use of an Et3GeNa/C6H5SCF3 combination is described. This reaction proceeded smoothly to give the desired compound in excellent yield.

Palladium(II)-Catalyzed Enantioselective Synthesis of α-(Trifluoromethyl)arylmethylamines

We describe a method for the synthesis of α-(trifluoromethyl)arylmethylamines that consists of the palladium(II)-catalyzed addition of arylboroxines to imines derived from trifluoroacetaldehyde. Palladium acetate is used as a catalyst with electron-neutral or electron-rich arylboroxines, and it was found that addition of an ammonium or silver salt was crucial to promote the reaction of electron-poor boroxines. With (S)-t-Bu-PyOX as the chiral ligand, this method delivers a variety of α-trifluoromethylated amines in 57-91% yield and with greater than 92% ee in most cases.

Enantioselective Pd-catalyzed hydrogenation of fluorinated imines: Facile access to chiral fluorinated amines

An enantioselective hydrogenation of simple fluorinated imines has been developed using Pd(OCOCF3)2/(R)-Cl-MeO-BIPHEP as a catalyst, and up to 94% ee was achieved. This method provides an efficient route to enantioenriched fluorinated amines.