193281-00-4

Basic information

• Product Name: N-[4-[2-(2-AMino-4,5,6,7-tetrahydro-4,6-dioxo-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]-L-glutaMic Acid
• Synonyms: LY 338979;N-[4-[2-(2-AMino-4,5,6,7-tetrahydro-4,6-dioxo-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]-L-glutaMic Acid;PeMetrexed IMpurity (Mixture of DiastereoMers) (N-[4-[2-(2-AMino-4,5,6,7-tetrahydro-4,6-dioxo-1H-pyrrolo[2.3-d]-pyriMidi;Pemetrexed 6-Oxo Diacid Impurity
• CAS NO: 193281-00-4
• Molecular Formula: C₂₀H₂₁N₅O₇
• Molecular Weight: 443.41004
• Product Categories: Aromatics, Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 193281-00-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.67±0.1 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, Refrigerator, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
• PKA: 3.59±0.10(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: N-[4-[2-(2-AMino-4,5,6,7-tetrahydro-4,6-dioxo-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]-L-glutaMic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-[2-(2-AMino-4,5,6,7-tetrahydro-4,6-dioxo-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]-L-glutaMic Acid(193281-00-4)
• EPA Substance Registry System: N-[4-[2-(2-AMino-4,5,6,7-tetrahydro-4,6-dioxo-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]-L-glutaMic Acid(193281-00-4)

Safety Data

• Hazardous Substances Data: 193281-00-4(Hazardous Substances Data)

Usage

Uses

LY 338979 is a metabolite of the antifolate Pemetrexed (P219500).

Upstream product

• 1320346-37-9 C₁₂H₁₂Br₂O₃ 
• 1320346-43-7 methyl 4-[2-(2-amino-4,6-dioxo-4,5,6,7-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoate 
• 193265-47-3 4-[2-(2-amino-4,6-dioxo-4,5,6,7-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoic acid 
• 1320346-45-9 dimethyl 2-{4-[2-(2-amino-4,6-dioxo-4,5,6,7-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-pentanedioate 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 106200-41-3 4-(4-carbomethoxyphenyl)butanal 
• 182009-04-7 N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-D-glutamic acid 

Relevant articles and documents

Preparation method of related substance of pemetrexed and medicinal salts thereof

The invention discloses a preparation method of a related substance of pemetrexed and medicinal salts thereof. The structure of related substance of pemetrexed and medicinal salts thereof is shown asa formula (I). The related substance is prepared by one-step reaction of pemetrexed and an oxidizing agent under the action of a catalyst. The simple and convenient preparation method of related substance of pemetrexed and medicinal salts thereof is provided, and provides a new way for further identifying, separating, preparing and characterizing the oxidation related substance of pemetrexed and medicinal salts thereof and improving the quality control level and medication safety of pemetrexed and medicinal salts thereof.